[Term]
id: PR:000003106
name: map kinase p38
def: "A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (environmental stress, pro-inflammatory cytokines and lipopolysaccharide) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY." [PRO:CNA]
comment: Category=family.
synonym: "fam:MAPKp38" EXACT PRO-short-label [PRO:DAN]
xref: PIRSF:PIRSF500943
is_a: PR:000000001 ! protein