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Protein Ontology Report - anaphase-promoting complex

GO:0005680 -
Ontology Information
PRO ID GO:0005680 Show OBO stanza
PRO name anaphase-promoting complex
Other: EXACT: anaphase promoting complex
Definition A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]
Comment Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
PRO Category
Parent GO:0031461 cullin-RING ubiquitin ligase complex
Term Hierarchy Visualization DAG     OLS     Cytoscape