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Protein Ontology Report - cyclin-dependent protein kinase activating kinase holoenzyme complex

GO:0019907 -
Ontology Information
PRO ID GO:0019907 Show OBO stanza
PRO name cyclin-dependent protein kinase activating kinase holoenzyme complex
Other: EXACT: CAK complex
Definition A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. [GOC:bhm, PMID:8752210]
PRO Category
Parent GO:0000307 cyclin-dependent protein kinase holoenzyme complex
Term Hierarchy Visualization DAG     OLS     Cytoscape