| PRO ID |
GO:0019907
Show OBO stanza
|
| PRO name |
cyclin-dependent protein kinase activating kinase holoenzyme complex |
| Synonyms |
| Other: |
EXACT: |
CAK complex |
|
| Definition |
A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH.
[GOC:bhm, PMID:8752210]
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| PRO Category |
|
| Parent |
GO:0000307 cyclin-dependent protein kinase holoenzyme complex |
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
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