Protein Ontology Report - GAIT complexGO:0097452 - http://purl.obolibrary.org/obo/GO_0097452 |
Ontology Information | ||||
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PRO ID | GO:0097452 Show OBO stanza | |||
PRO name | GAIT complex | |||
Synonyms |
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Definition | A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. [GOC:br, PMID:15479637, PMID:23071094] | |||
PRO Category | ||||
Parent | GO:0032991 protein-containing complex | |||
Term Hierarchy Visualization | DAG OLS Cytoscape |
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