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Protein Ontology Report - HECT domain-containing E3 ubiquitin-protein ligase with WW domains

PR:000000016 - http://purl.obolibrary.org/obo/PR_000000016
Ontology Information
PRO ID PR:000000016 Show OBO stanza / PAF
PRO name HECT domain-containing E3 ubiquitin-protein ligase with WW domains
Definition A protein with a core domain composition consisting of the C-terminal HECT-domain (ubiquitin-transferase) (Pfam:PF00632), which is catalytically involved in the attachment of ubiquitin to substrate proteins, and an N-terminal extension with a C2 domain (Pfam:PF00168) and two to three copies of the WW domain (Pfam:PF00397) that mediate the substrate specificity. [PMID:18047743]
PRO Category family
Parent PR:000000001 protein
Term Hierarchy Visualization DAG     OLS     Cytoscape


Functional Annotation
PRO Term GO Annotation Evidence
PR:000000016
HECT domain-containing E3 ubiquitin-protein ligase with WW domains
capable_of GO:0004842 ubiquitin-protein transferase activity PIRSF:PIRSF001569
has_part Pfam:PF00397 WW domain PIRSF:PIRSF001569
has_part Pfam:PF00168 C2 domain PIRSF:PIRSF001569
has_part Pfam:PF00632 HECT-domain (ubiquitin-transferase) PIRSF:PIRSF001569

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