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Protein Ontology Report - BMPR1A

PR:000000035 - http://purl.obolibrary.org/obo/PR_000000035
Ontology Information
PRO ID PR:000000035 Show OBO stanza / PAF
PRO name BMP receptor type-1A
Synonyms
PRO-short-label: EXACT: BMPR1A
Gene-based: RELATED: ACVRLK3 | ALK3 | Bmpr
Other: EXACT: ALK-3 | BMP type-1A receptor | BMP-2/BMP-4 receptor | BMPR-1A | CD292 | SKR5 | activin receptor-like kinase 3 | serine/threonine-protein kinase receptor R5
Definition A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1A gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2 and BMP4. [PRO:CNA]
PRO Category gene
Parent PR:000000006 TGF-beta superfamily receptor type-1
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 10
modification 3 organism-modification 5
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000138
hBMPR1A/var:C82Y
Cys-82, CHEBI:46858 		associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000139
hBMPR1A/var:C124R
Cys-124, CHEBI:29952 		associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:11536076
PR:000000144
hBMPR1A/var:M470T
Met-470, CHEBI:30013 		associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12630959
PR:000000141
hBMPR1A/var:A338D
Ala-338, CHEBI:29958 		associated_with_disease_progression DOID:6457 Cowden syndrome PMID:11536076
PR:000000140
hBMPR1A/var:C130R
Cys-130, CHEBI:29952 		associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12136244
PR:000000143
hBMPR1A/var:R443C
Arg-443, CHEBI:29950 		associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513, PMID:17344846
PR:000000142
hBMPR1A/var:C376Y
Cys-376, CHEBI:46858 		associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:11536076
PR:000036423
mBMPR1A/iso:1/Phos:1
enables GO:0046332 SMAD binding PMID:10814522, PMID:9738003
PR:000036422
hBMPR1A/iso:1/Phos:1
acts_upstream_of_or_within GO:0006468 protein phosphorylation PMID:12065756
acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:12829744
enables GO:0004674 protein serine/threonine kinase activity PMID:12829744
located_in GO:0009986 cell surface PMID:10712517
part_of GO:0043235 receptor complex PMID:12829744, PMID:15940369
PR:P36895-1
mBMPR1A/iso:1
acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:10814522
PR:P36894-1
hBMPR1A/iso:1
located_in GO:0016020 membrane PMID:8397373
part_of GO:0043235 receptor complex PMID:15940369
PR:000000137
hBMPR1A/var:Y62D
Tyr-62, CHEBI:29958 		associated_with_disease_progression DOID:0050787 juvenile polyposis syndrome PMID:12417513
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0016020 membrane PR:P36894-1 hBMPR1A/iso:1

PMID:8397373
GO:0009986 cell surface PR:000036422 hBMPR1A/iso:1/Phos:1

PMID:10712517

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