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Protein Ontology Report - CUL1

PR:000000092 - http://purl.obolibrary.org/obo/PR_000000092
Ontology Information
PRO ID PR:000000092 Show OBO stanza / PAF
PRO name fungal/metazoan cullin-1
Synonyms
PRO-short-label: CUL1
EXACT: CUL-1
Definition A cullin that is a translation product of the human CUL1 gene or a 1:1 ortholog thereof in fungi or metazoa. [PRO:CNA]
PRO Category gene
Parent PR:000000013 cullin
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 7
sequence 1 organism-sequence 2
modification 2 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

CUL1 forms found in complexes
CUL1 Component Complexes
PR:Q13616 hCUL1 PR:000026772 SCF(Skp2) complex (human)
PR:Q13616 hCUL1 PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
PR:Q13616 hCUL1 PR:000026771 SCF beta-TrCP complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000092
CUL1
part_of GO:0019005 SCF ubiquitin ligase complex PANTHER:PTHR11932:SF19
participates_in GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PANTHER:PTHR11932:SF19
PR:000036454
hCUL1/iso:1/Nedd:1
Lys-720, MOD:01150
part_of GO:0019005 SCF ubiquitin ligase complex PMID:10713156, PMID:10921923, PMID:17098746
participates_in GO:0007050 cell cycle arrest PMID:8681378
participates_in GO:0097193 intrinsic apoptotic signaling pathway PMID:8681378
participates_in GO:0008285 negative regulation of cell proliferation PMID:8681378
participates_in GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PMID:10713156, PMID:10921923
PR:Q13616-1
hCUL1/iso:1
capable_of GO:0005515 protein binding with PR:P62877-1 hRBX1/iso:1 PMID:12504026, PMID:15537541
capable_of GO:0005515 protein binding with PR:Q86VP6-1 hCAND1/iso:1 PMID:12504026, PMID:15537541
part_of NOT GO:0019005 SCF ubiquitin ligase complex PMID:10713156, PMID:10921923, PMID:12504026
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0008285 negative regulation of cell proliferation PR:000036454 hCUL1/iso:1/Nedd:1
Lys-720, MOD:01150
PMID:8681378
GO:0007050 cell cycle arrest PR:000036454 hCUL1/iso:1/Nedd:1
Lys-720, MOD:01150
PMID:8681378
GO:0097193 intrinsic apoptotic signaling pathway PR:000036454 hCUL1/iso:1/Nedd:1
Lys-720, MOD:01150
PMID:8681378
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PR:000000092 CUL1

PANTHER:PTHR11932:SF19
PR:000036454 hCUL1/iso:1/Nedd:1
Lys-720, MOD:01150
PMID:10713156, PMID:10921923

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