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Protein Ontology Report - MAPK1

PR:000000103 - http://purl.obolibrary.org/obo/PR_000000103
Ontology Information
PRO ID PR:000000103 Show OBO stanza / PAF
PRO name mitogen-activated protein kinase 1
Synonyms
PRO-short-label: MAPK1
EXACT: ERK-2; ERT1; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; extracellular signal-regulated kinase 2; mitogen-activated protein kinase 2; p42-MAPK
Gene-based: ERK2; Mapk; PRKM1; PRKM2
Definition A mitogen-activated protein kinase that is a translation product of the human MAPK1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000019 mitogen-activated protein kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 1 organism-sequence 5
modification 6 organism-modification 6
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036466
rMAPK1/iso:1/Phos:1
Thr-183, MOD:00047|Tyr-185, MOD:00048
capable_of GO:0042803 protein homodimerization activity PMID:9604935
PR:000036464
mMAPK1/iso:1/Phos:1
Thr-183, MOD:00047|Tyr-185, MOD:00048
capable_of GO:0004672 protein kinase activity PMID:14744933
capable_of GO:0004707 MAP kinase activity PMID:11684667, PMID:12223545, PMID:15314156, PMID:8626447
located_in GO:0005634 nucleus PMID:11726647, PMID:12925581, PMID:16251435
participates_in GO:0007165 signal transduction PMID:11684667
participates_in GO:0006468 protein phosphorylation PMID:15284227
participates_in GO:0000165 MAPK cascade PMID:8626447
PR:P63085-1
mMAPK1/iso:1
located_in GO:0005737 cytoplasm PMID:11726647, PMID:12223545
PR:P28482-1
hMAPK1/iso:1
capable_of NOT GO:0004707 MAP kinase activity PMID:10706854
participates_in GO:0006950 response to stress PMID:10958679
participates_in GO:0006935 chemotaxis PMID:10706854
participates_in GO:0007268 chemical synaptic transmission PMID:10706854
PR:000026341
hMAPK1/iso:1/Phos:1
Thr-185, MOD:00047|Tyr-187, MOD:00048
capable_of GO:0005515 protein binding PMID:16291755
capable_of GO:0004707 MAP kinase activity PMID:10706854
capable_of GO:0004672 protein kinase activity PMID:10706854
participates_in GO:0007165 signal transduction PMID:1540184
participates_in GO:0006935 chemotaxis PMID:10706854
participates_in GO:0006915 apoptotic process PMID:10958679
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006915 apoptotic process PR:000026341 hMAPK1/iso:1/Phos:1
Thr-185, MOD:00047|Tyr-187, MOD:00048
PMID:10958679
GO:0006950 response to stress PR:P28482-1 hMAPK1/iso:1

PMID:10958679
GO:0007268 chemical synaptic transmission PR:P28482-1 hMAPK1/iso:1

PMID:10706854
GO:0006935 chemotaxis PR:000026341 hMAPK1/iso:1/Phos:1
Thr-185, MOD:00047|Tyr-187, MOD:00048
PMID:10706854
PR:P28482-1 hMAPK1/iso:1

PMID:10706854
GO:0007165 signal transduction PR:000026341 hMAPK1/iso:1/Phos:1
Thr-185, MOD:00047|Tyr-187, MOD:00048
PMID:1540184
PR:000036464 mMAPK1/iso:1/Phos:1
Thr-183, MOD:00047|Tyr-185, MOD:00048
PMID:11684667
GO:0000165 MAPK cascade PR:000036464 mMAPK1/iso:1/Phos:1
Thr-183, MOD:00047|Tyr-185, MOD:00048
PMID:8626447
GO:0006468 protein phosphorylation PR:000036464 mMAPK1/iso:1/Phos:1
Thr-183, MOD:00047|Tyr-185, MOD:00048
PMID:15284227
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000036464 mMAPK1/iso:1/Phos:1
Thr-183, MOD:00047|Tyr-185, MOD:00048
PMID:11726647, PMID:12925581, PMID:16251435
GO:0005737 cytoplasm PR:P63085-1 mMAPK1/iso:1

PMID:11726647, PMID:12223545

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