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Protein Ontology Report - ZFYVE9

PR:000000125 - http://purl.obolibrary.org/obo/PR_000000125
Ontology Information
PRO ID PR:000000125 Show OBO stanza / PAF
PRO name sara
Synonyms
PRO-short-label: ZFYVE9
EXACT: Madh-interacting protein; mothers against decapentaplegic homolog-interacting protein; novel serine protease; receptor activation anchor; smad anchor for receptor activation
RELATED: MADHIP; NSP; SARA; SMADIP
Definition A sara-type zinc finger FYVE domain-containing protein that is a translation product of the human ZFYVE9 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000026 sara-type zinc finger FYVE domain-containing protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 3 organism-sequence 5
modification 1 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

ZFYVE9 forms found in complexes
ZFYVE9 Component Complexes
PR:000000125 ZFYVE9 PR:000025974 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex
PR:O95405 hZFYVE9 PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:O95405-2
hZFYVE9/iso:2
located_in GO:0005615 extracellular space PMID:9582421
PR:O95405-3
hZFYVE9/iso:3
located_in GO:0005615 extracellular space PMID:9582421
PR:000000125
ZFYVE9
participates_in GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PANTHER:PTHR22835:SF7
PR:O95405-1
hZFYVE9/iso:1
capable_of GO:0005515 protein binding with PR:P08100 hRHO PMID:17693260
capable_of GO:0005515 protein binding with PR:000025960 hSMAD2/iso:[Long/Short]/UnPhos:1 PMID:11877415, PMID:9865696
located_in GO:0005769 early endosome PMID:11877415, PMID:12356868, PMID:12432064
participates_in GO:0007183 SMAD protein complex assembly PMID:11877415, PMID:12356868
participates_in GO:0006897 endocytosis PMID:12809483
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:10615055
participates_in GO:0060390 regulation of SMAD protein signal transduction PMID:11877415, PMID:12356868
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007183 SMAD protein complex assembly PR:O95405-1 hZFYVE9/iso:1

PMID:11877415, PMID:12356868
GO:0006897 endocytosis PR:O95405-1 hZFYVE9/iso:1

PMID:12809483
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PR:000000125 ZFYVE9

PANTHER:PTHR22835:SF7
GO:0007179 transforming growth factor beta receptor signaling pathway PR:O95405-1 hZFYVE9/iso:1

PMID:10615055
GO:0060390 regulation of SMAD protein signal transduction PR:O95405-1 hZFYVE9/iso:1

PMID:11877415, PMID:12356868
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005769 early endosome PR:O95405-1 hZFYVE9/iso:1

PMID:11877415, PMID:12356868, PMID:12432064
GO:0005615 extracellular space PR:O95405-2 hZFYVE9/iso:2

PMID:9582421
PR:O95405-3 hZFYVE9/iso:3

PMID:9582421

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