PRO Entry Report - PR:000000129

Protein Ontology Report - THBS1

PR:000000129 - http://purl.obolibrary.org/obo/PR_000000129

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:000000129 Show OBO stanza / PAF

PRO name

thrombospondin-1

Synonyms

PRO-short-label:	EXACT:	THBS1
Gene-based:	RELATED:	TSP \| TSP1
Other:	EXACT:	glycoprotein G

Definition

A thrombospondin subgroup A that is a translation product of the human THBS1 gene or a 1:1 ortholog thereof. [PRO:CNA]

PRO Category

gene

Parent

PR:000000029 thrombospondin subgroup A

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
gene	1	organism-gene	2
sequence	1	organism-sequence	3
modification	7	organism-modification	15
union	0

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

THBS1 forms found in complexes

THBS1 Component	Complexes
PR:000028410 hTHBS1/SigPep-	PR:000028445 integrin alphaIIbbeta3:thrombospondin 1 (human)

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000000129 THBS1	acts_upstream_of_or_within	GO:0007596 blood coagulation	PANTHER:PTHR10199:SF37
PR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+ MOD:00222\|MOD:00812\|MOD:00813	enables	GO:0050431 transforming growth factor beta binding	PMID:9657149
	enables	GO:0005515 protein binding with PR:000036486 mTHBS1/iso:1/Clv:2	PMID:1459996
	located_in	GO:0005615 extracellular space	PMID:9657149
PR:000028410 hTHBS1/SigPep-	located_in	GO:0005615 extracellular space	PMID:15662972
PR:000036485 mTHBS1/iso:1/SigPep-	located_in	GO:0005615 extracellular space	PMID:12498716
PR:000036490 mTHBS1/iso:1/Clv:2/GlycoRes+ MOD:00693	acts_upstream_of_or_within	GO:0016525 negative regulation of angiogenesis	PMID:17082774
PR:000036490 mTHBS1/iso:1/Clv:2/GlycoRes+ MOD:00693	acts_upstream_of_or_within	GO:0060055 angiogenesis involved in wound healing	PMID:17082774
PR:000036486 mTHBS1/iso:1/Clv:2	acts_upstream_of_or_within	GO:0060055 angiogenesis involved in wound healing	PMID:17082774
	acts_upstream_of_or_within	GO:0016525 negative regulation of angiogenesis	PMID:17082774
	enables	GO:0042802 identical protein binding with PR:000036486 mTHBS1/iso:1/Clv:2	PMID:17082774
PR:000036488 hTHBS1/iso:1/SigPep-/Glyco:1 Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222\|Ser-394, MOD:00812\|Thr-450/Thr-507, MOD:00813	enables	GO:0050431 transforming growth factor beta binding	PMID:15342643
	enables	GO:0005515 protein binding with PR:000028966 hTHBS1/iso:1/Clv:2	PMID:3305519
PR:000044495 mTHBS1/SigPep-	located_in	GO:0005615 extracellular space	PMID:12498716
PR:000026338 hTHBS1/iso:1/SigPep-	enables	GO:0004866 endopeptidase inhibitor activity	PMID:8751720
PR:000026338 hTHBS1/iso:1/SigPep-	located_in	GO:0005615 extracellular space	PMID:15662972

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005615 extracellular space	PR:000026338 hTHBS1/iso:1/SigPep-	PMID:15662972
	PR:000028410 hTHBS1/SigPep-	PMID:15662972
	PR:000036485 mTHBS1/iso:1/SigPep-	PMID:12498716
	PR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+ MOD:00222\|MOD:00812\|MOD:00813	PMID:9657149
	PR:000044495 mTHBS1/SigPep-	PMID:12498716

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