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Protein Ontology Report - SMAD5

PR:000000372 - http://purl.obolibrary.org/obo/PR_000000372
Ontology Information
PRO ID PR:000000372 Show OBO stanza / PAF
PRO name smad5
Synonyms
PRO-short-label: EXACT: SMAD5
Gene-based: RELATED: MADH5
Other: EXACT: Dwf-C | JV5-1 | MAD homolog 5 | SMAD 5 | SMAD family member 5 | Smad5 | dwarfin-C | mothers against DPP homolog 5
Definition A BMP receptor-regulated smad protein that is a translation product of the human SMAD5 gene or a 1:1 ortholog thereof. [PMID:10708949]
PRO Category gene
Parent PR:000000038 BMP receptor-regulated smad protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 2 organism-sequence 3
modification 4 organism-modification 4
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036562
hSMAD5/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046 		acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:8637600
enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135
PR:000036563
mSMAD5/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046 		acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:16522160
located_in GO:0005634 nucleus PMID:10504300, PMID:9759503
PR:P97454-1
mSMAD5/iso:1
acts_upstream_of_or_within GO:0007165 signal transduction PMID:16765933
acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:16522160, PMID:16765933
located_in GO:0005737 cytoplasm PMID:10504300
PR:000029962
hSMAD5/iso:2
enables NOT GO:0046332 SMAD binding PMID:10845932
PR:Q99717-1
hSMAD5/iso:1
acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:8673135
enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000036563 mSMAD5/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046
PMID:10504300, PMID:9759503
GO:0005737 cytoplasm PR:P97454-1 mSMAD5/iso:1

PMID:10504300

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