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Protein Ontology Report - SMAD6

PR:000000373 - http://purl.obolibrary.org/obo/PR_000000373
Ontology Information
PRO ID PR:000000373 Show OBO stanza / PAF
PRO name smad6
Synonyms
PRO-short-label: SMAD6
EXACT: MAD homolog 6; Mad homolog 7; SMAD 6; SMAD family member 6; mothers against DPP homolog 6
RELATED: MADH6; Madh7; Msmad6
Definition An inhibitory smad protein that is a translation product of the human SMAD6 gene or a 1:1 ortholog thereof. Inhibitor of bone morphogenetic protein (BMP) signaling, and the interaction with BMP type 1 receptors is a critical step in the function of smad6. [PMID:17493940]
PRO Category gene
Parent PR:000000099 inhibitory smad protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 2 organism-sequence 4
modification 2 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:O43541-1
hSMAD6/iso:A
capable_of GO:0005515 protein binding with PR:000026334 hSMAD1/iso:1/Phos:1 PMID:9436979
capable_of GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity PMID:9436979
PR:O43541-2
hSMAD6/iso:B
capable_of GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity PMID:11284962
capable_of GO:0005515 protein binding PMID:11284962
capable_of GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity PMID:11284962
has_part NOT Pfam:PF03165 MH1 domain PMID:11284962
PR:O35182-1
mSMAD6/iso:1
capable_of GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity PMID:17118358
PR:000036564
mSMAD6/iso:1/Me2:1
Arg-74, MOD:00783
capable_of GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity PMID:17118358

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