Protein Ontology Report - hTGFB1/var:H222D PR:000000402 - http://purl.obolibrary.org/obo/PR_000000402

Ontology Information
PRO ID	PR:000000402 Show OBO stanza / PAF / GPI
PRO name	TGF-beta 1 sequence variant H222D (human)
Synonyms	PRO-short-label: EXACT: hTGFB1/var:H222D PRO-proteoform-std: EXACT: UniProtKB:P01137, His-222, CHEBI:29958 Other: EXACT: TGF-beta 1 sequence variant 5 (human)
Definition	A transforming growth factor beta-1 (human) that has an Asp residue at the position equivalent to His-222 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, His-222, CHEBI:29958. [PMID:12493741, PRO:CNA, PRO:DAN]
PRO Category	organism-sequence
Parent	PR:P01137 transforming growth factor beta-1 (human)
Taxon	NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	UniProtKB_VAR:VAR_017610

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PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View
PRO Term GO Annotation Evidence PR:000000402 hTGFB1/var:H222D His-222, CHEBI:29958 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:12493741 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741 associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:12493741

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