| PRO ID |
PR:000000670
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/ PAF
|
| PRO name |
cation channel sperm-associated protein 2 |
| Synonyms |
| PRO-short-label: |
EXACT: |
CATSPER2 |
| Other: |
EXACT: |
CatSper2 |
|
| Definition |
A CatSper channel protein that is a translation product of the human CATSPER2 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper2 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane.
[PRO:CNA]
|
| PRO Category |
gene |
| Parent |
PR:000044645 CatSper channel protein |
| Terms by PRO Category |
Retrieve All terms OBO Stanza
/ PAF
| Organism-Independent |
Organism-Specific |
| Category |
Number of Terms |
Category |
Number of Terms |
|
gene
|
1 |
organism-gene
|
3 |
|
sequence
|
4 |
organism-sequence
|
5 |
|
modification
|
0 |
organism-modification
|
0 |
|
union
|
0 |
|
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