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Protein Ontology Report - CATSPER3

PR:000000671 -
Ontology Information
PRO ID PR:000000671 Show OBO stanza / PAF
PRO name cation channel sperm-associated protein 3
PRO-short-label: CATSPER3
EXACT: Ca(v)-like protein; CatSper3; one-repeat calcium channel-like protein
Definition A CatSper channel protein that is a translation product of the human CATSPER3 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper3 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. [PRO:CNA]
PRO Category gene
Parent PR:000044645 CatSper channel protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 2 organism-sequence 3
modification 0 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
capable_of GO:0005515 protein binding with PR:Q91ZR5-1 mCATSPER1/iso:1 PMID:17227845
located_in GO:0001669 acrosomal vesicle PMID:16107607
participates_in GO:0030317 flagellated sperm motility PMID:17227845
participates_in GO:0001539 cilium or flagellum-dependent cell motility PMID:17227845
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0030317 flagellated sperm motility PR:Q80W99 mCATSPER3

GO:0001539 cilium or flagellum-dependent cell motility PR:Q80W99 mCATSPER3

Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0001669 acrosomal vesicle PR:Q80W99 mCATSPER3