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Protein Ontology Report - potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein

PR:000000676 - http://purl.obolibrary.org/obo/PR_000000676
Ontology Information
PRO ID PR:000000676 Show OBO stanza / PAF
PRO name potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
Synonyms
EXACT: f-channel
RELATED: HCN
Definition A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The N terminus has a conserved domain that is also present in other voltage-gated potassium and sodium channels. The carboxyl-terminal region contains the cyclic nucleotide-binding domain (CNBD). In addition, there is a structural element called the C-linker, the region connecting the CNBD to the S6 segment, which couples conformational changes in the ligand-binding domain to channel activation. Subunits combine to form the HCN channels. In common with CNG channels, HCN are cation channels that are modulated by cyclic nucleotide binding. Unlike CNG channels, HCN channels are voltage-gated, and are weakly selective for potassium. In contrast to most other voltage-gated channels, HCN channels open upon hyperpolarization and close at positive potential. HCN channels act as a pacemaker by regulating neuronal and cardiac firing rate, but also function as a regulator of membrane resting potential and resistance. [PMID:16382102]
PRO Category family
Parent PR:000044648 cyclic nucleotide-regulated channel protein
Term Hierarchy Visualization DAG     OLS     Cytoscape


Functional Annotation
PRO Term GO Annotation Evidence
PR:000000676
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
has_part Pfam:PF00027 Cyclic nucleotide-binding domain PIRSF:PIRSF038514
has_part Pfam:PF08412 Ion transport protein N-terminal PIRSF:PIRSF038514
has_part Pfam:PF00520 Ion transport protein PIRSF:PIRSF038514

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