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Protein Ontology Report - NALCN

PR:000000678 - http://purl.obolibrary.org/obo/PR_000000678
Ontology Information
PRO ID PR:000000678 Show OBO stanza / PAF
PRO name sodium leak channel non-selective protein
Synonyms
PRO-short-label: NALCN
EXACT: CanIon; voltage gated channel-like protein 1
RELATED: VGCNL1
Definition An ion channel protein that is a translation product of the human NALCN gene or a 1:1 ortholog thereof. The prototype subunit contains four copies of the six transmembrane ion transport protein domain, but the number of copies of this domain varies among splice variants. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. They are subunits of a voltage-independent, nonselective cation channel. [PMID:17448995, PRO:CNA]
Comment Note: NALCN operates as part of a complex with UNC80 (PR:000017098) and UNC79 (PR:000030850) that together form a fucntional channel. [PRO:DAN, PMID:21040849]
PRO Category gene
Parent PR:000049983 ion channel protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 3 organism-sequence 5
modification 0 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000717
NALCN/iso:3
has_part NOT Pfam:PF00520 Ion transport protein
PR:000000678
NALCN
capable_of GO:0005216 ion channel activity PIRSF:PIRSF038547
has_part Pfam:PF00520 Ion transport protein PIRSF:PIRSF038547
participates_in GO:0006811 ion transport PIRSF:PIRSF038547
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006811 ion transport PR:000000678 NALCN

PIRSF:PIRSF038547

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