back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Wiki
 PRO Consortium
 Publications
 Documentation

Protein Ontology Report - fam:TRPC

PR:000000680 - http://purl.obolibrary.org/obo/PR_000000680
Ontology Information
PRO ID PR:000000680 Show OBO stanza / PAF
PRO name transient receptor potential cation channel TRPC
Synonyms
PRO-short-label: fam:TRPC
Definition A transient receptor potential channel protein that is a member of the subfamily C of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains up to 4 detectable copies of Ankyrin repeat (Pfam:PF00023) followed by the Transient receptor ion channel II domain (Pfam:PF08344). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means. [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB]
PRO Category family
Parent PR:000044657 transient receptor potential channel protein
Term Hierarchy Visualization DAG     OLS     Cytoscape


Functional Annotation
PRO Term GO Annotation Evidence
PR:000000680
fam:TRPC
has_part Pfam:PF00023 Ankyrin repeat PIRSF:PIRSF005528
has_part Pfam:PF00520 Ion transport protein PIRSF:PIRSF005528
has_part Pfam:PF08344 Transient receptor ion channel II PIRSF:PIRSF005528

top