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Protein Ontology Report - fam:Kchan_sub-a_PAS

PR:000000682 -
Ontology Information
PRO ID PR:000000682 Show OBO stanza / PAF
PRO name voltage-gated potassium channel alpha subunit with PAS domain
PRO-short-label: fam:Kchan_sub-a_PAS
Definition A voltage-gated potassium channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. Unique to this class is the presence of an N-terminal PAS fold domain (Pfam:PF00989). In addition, in the cytoplasmic region downstream from S6, there is a segment that shares substantial similarity to the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) present in cyclic nucleotide-gated cation channel subunits (PR:000000674 and PR:000000674). These channels regulate membrane excitability. [PMID:8159766]
PRO Category family
Parent PR:000044654 voltage-gated potassium channel protein
Term Hierarchy Visualization DAG     OLS     Cytoscape

Functional Annotation
PRO Term GO Annotation Evidence
capable_of GO:0005249 voltage-gated potassium channel activity PIRSF:PIRSF038287
has_part Pfam:PF00520 Ion transport protein PIRSF:PIRSF038287
has_part Pfam:PF00027 Cyclic nucleotide-binding domain PIRSF:PIRSF038287
has_part Pfam:PF00989 PAS fold PIRSF:PIRSF038287
part_of GO:0008076 voltage-gated potassium channel complex PIRSF:PIRSF038287