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||voltage-gated potassium channel alpha subunit with PAS domain
|| A voltage-gated potassium channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. Unique to this class is the presence of an N-terminal PAS fold domain (Pfam:PF00989). In addition, in the cytoplasmic region downstream from S6, there is a segment that shares substantial similarity to the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) present in cyclic nucleotide-gated cation channel subunits (PR:000000674 and PR:000000674). These channels regulate membrane excitability.
|| PR:000044654 voltage-gated potassium channel protein
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