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Protein Ontology Report - PDGFC

PR:000000703 - http://purl.obolibrary.org/obo/PR_000000703
Ontology Information
PRO ID PR:000000703 Show OBO stanza / PAF
PRO name platelet-derived growth factor C
Synonyms
PRO-short-label: EXACT: PDGFC
Gene-based: RELATED: SCDGF | UNQ174/PRO200
Other: EXACT: PDGF-C | VEGF-E | fallotein | spinal cord-derived growth factor
Definition A platelet-derived growth factor with CUB domain that is a translation product of the human PDGFC gene or a 1:1 ortholog thereof. Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. [PRO:CNA]
PRO Category gene
Parent PR:000000675 platelet-derived growth factor with CUB domain
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 5
modification 5 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036571
mPDGFC/iso:1/Clv:1
acts_upstream_of_or_within GO:0042060 wound healing PMID:11297552
located_in GO:0005615 extracellular space PMID:15372073
PR:000036570
hPDGFC/iso:1/Clv:1
enables GO:0005102 signaling receptor binding PMID:10806482, PMID:11297552
enables GO:0008083 growth factor activity PMID:10806482, PMID:11297552
located_in GO:0005615 extracellular space PMID:15911618
PR:000036572
hPDGFC/iso:1/Sumo1+
MOD:01149~PR:000050074
located_in GO:0005634 nucleus PMID:16443219
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000036572 hPDGFC/iso:1/Sumo1+
MOD:01149~PR:000050074
PMID:16443219
GO:0005615 extracellular space PR:000036570 hPDGFC/iso:1/Clv:1

PMID:15911618
PR:000036571 mPDGFC/iso:1/Clv:1

PMID:15372073

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