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Protein Ontology Report - PTPRC

PR:000001006 - http://purl.obolibrary.org/obo/PR_000001006
Ontology Information
PRO ID PR:000001006 Show OBO stanza / PAF
PRO name receptor-type tyrosine-protein phosphatase C
Synonyms
PRO-short-label: EXACT: PTPRC
Gene-based: RELATED: CD45
Other: EXACT: L-CA | leukocyte common antigen | ly-5 | lymphocyte antigen 5
BROAD: T200
Definition A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule. [PMID:1351092, PRO:CNA]
Comment Requested by=CL.
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 8 organism-sequence 22
modification 17 organism-modification 4
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000050324
mPtprc/iso:x1
located_in GO:0009897 external side of plasma membrane MGI:77755, PMID:8566025
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0009897 external side of plasma membrane PR:000050324 mPtprc/iso:x1

MGI:77755, PMID:8566025

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