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Protein Ontology Report - PTPRC

PR:000001006 - http://purl.obolibrary.org/obo/PR_000001006
Ontology Information
PRO ID PR:000001006 Show OBO stanza / PAF
PRO name receptor-type tyrosine-protein phosphatase C
Synonyms
PRO-short-label: PTPRC
BROAD: T200
EXACT: CD45; L-CA; leukocyte common antigen; ly-5; lymphocyte antigen 5
Definition A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule. [PMID:1351092, PRO:CNA]
Comment Requested by=CL.
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 8 organism-sequence 19
modification 17 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000001006
PTPRC
has_part Pfam:PF00102 Protein-tyrosine phosphatase PIRSF:PIRSF002004
has_part Pfam:PF00041 Fibronectin type III domain PIRSF:PIRSF002004

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