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Protein Ontology Report - DRD2

PR:000001177 - http://purl.obolibrary.org/obo/PR_000001177
Ontology Information
PRO ID PR:000001177 Show OBO stanza / PAF
PRO name D(2) dopamine receptor
Synonyms
PRO-short-label: DRD2
EXACT: dopamine D2 receptor
Definition A D(2)-like dopamine receptor that is a translation product of the human DRD2 gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000001108 D(2)-like dopamine receptor
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 6
sequence 2 organism-sequence 17
modification 0 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P61168-2
mDRD2/iso:2
capable_of GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:3611062, PMID:12476322
capable_of GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:892768, PMID:1991517
participates_in GO:0060160 negative regulation of dopamine receptor signaling pathway MGI:2181304, PMID:11089973
participates_in GO:0014059 regulation of dopamine secretion MGI:3655899, PMID:11943831
participates_in GO:0051967 negative regulation of synaptic transmission, glutamatergic MGI:3628700, PMID:15489038
participates_in GO:0001975 response to amphetamine MGI:3611062, PMID:12476322
participates_in GO:0032228 regulation of synaptic transmission, GABAergic MGI:3628700, PMID:15489038
participates_in GO:0042220 response to cocaine MGI:3655899, PMID:11943831
participates_in GO:0043278 response to morphine MGI:3655899, PMID:11943831
PR:P61168-1
mDRD2/iso:1
capable_of GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:3611062, PMID:12476322
capable_of GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:893272, PMID:7706278
capable_of GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:1927281, PMID:11069937
capable_of GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:892768, PMID:1991517
located_in GO:0016020 membrane MGI:893272, PMID:7706278
participates_in GO:0007212 dopamine receptor signaling pathway MGI:2181304, PMID:11089973
participates_in GO:0032228 regulation of synaptic transmission, GABAergic MGI:3628700, PMID:15489038
participates_in GO:0007626 locomotory behavior MGI:1927281, PMID:11069937
participates_in GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway MGI:893272, PMID:7706278
participates_in GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway MGI:893272, PMID:7706278
participates_in GO:0060134 prepulse inhibition MGI:3611062, PMID:12476322
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0060134 prepulse inhibition PR:P61168-1 mDRD2/iso:1

MGI:3611062, PMID:12476322
GO:0043278 response to morphine PR:P61168-2 mDRD2/iso:2

MGI:3655899, PMID:11943831
GO:0060160 negative regulation of dopamine receptor signaling pathway PR:P61168-2 mDRD2/iso:2

MGI:2181304, PMID:11089973
GO:0007212 dopamine receptor signaling pathway PR:P61168-1 mDRD2/iso:1

MGI:2181304, PMID:11089973
GO:0032228 regulation of synaptic transmission, GABAergic PR:P61168-1 mDRD2/iso:1

MGI:3628700, PMID:15489038
PR:P61168-2 mDRD2/iso:2

MGI:3628700, PMID:15489038
GO:0051967 negative regulation of synaptic transmission, glutamatergic PR:P61168-2 mDRD2/iso:2

MGI:3628700, PMID:15489038
GO:0014059 regulation of dopamine secretion PR:P61168-2 mDRD2/iso:2

MGI:3655899, PMID:11943831
GO:0001975 response to amphetamine PR:P61168-2 mDRD2/iso:2

MGI:3611062, PMID:12476322
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway PR:P61168-1 mDRD2/iso:1

MGI:893272, PMID:7706278
PR:P61168-1 mDRD2/iso:1

MGI:893272, PMID:7706278
GO:0007626 locomotory behavior PR:P61168-1 mDRD2/iso:1

MGI:1927281, PMID:11069937
GO:0042220 response to cocaine PR:P61168-2 mDRD2/iso:2

MGI:3655899, PMID:11943831
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0016020 membrane PR:P61168-1 mDRD2/iso:1

MGI:893272, PMID:7706278

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