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Protein Ontology Report - TIRAP

PR:000001751 - http://purl.obolibrary.org/obo/PR_000001751
Ontology Information
PRO ID PR:000001751 Show OBO stanza / PAF
PRO name Toll/interleukin-1 receptor domain-containing adapter protein
Synonyms
PRO-short-label: TIRAP
EXACT: MyD88 adapter-like protein; TIR domain-containing adapter protein; adaptor protein Wyatt
Gene-based: MAL
Definition A protein that is a translation product of the human TIRAP gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 3
modification 2 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

TIRAP forms found in complexes
TIRAP Component Complexes
PR:000001751 TIRAP PR:000036006 TIRAP:PIP2 complex
PR:000001751 TIRAP PR:000025784 MYD88:TIRAP:activated TLR4 receptor
PR:000001751 TIRAP PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:000027214 hTIRAP/iso:1/Phos:1 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000027214 hTIRAP/iso:1/Phos:1 PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)
PR:000027214 hTIRAP/iso:1/Phos:1 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000027216 mTIRAP/Phos:1 PR:000037478 pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:000027216 mTIRAP/Phos:1 PR:000027217 pTIRAP:PIP2:activated TLR4 complex (mouse)
PR:P58753 hTIRAP PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:P58753 hTIRAP PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P58753 hTIRAP PR:000036014 TIRAP:PIP2 complex (human)
PR:P58753-1 hTIRAP/iso:1 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:P58753-1 hTIRAP/iso:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:P58753-1 hTIRAP/iso:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:Q4U127 chick-TIRAP PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)
PR:Q99JY1 mTIRAP PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:Q99JY1 mTIRAP PR:000036007 TIRAP:PIP2 complex (mouse)
PR:Q99JY1 mTIRAP PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:Q99JY1 mTIRAP PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse)
PR:Q99JY1 mTIRAP PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
PR:Q99JY1 mTIRAP PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:Q99JY1 mTIRAP PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:Q99JY1 mTIRAP PR:000027196 TIRAP:PIP2:activated TLR4 (mouse)
PR:Q99JY1 mTIRAP PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)
PR:Q99JY1 mTIRAP PR:000037477 TIRAP:PIP2:BTK:activated TLR4 complex (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000001751
TIRAP
has_part Pfam:PF01582 TIR domain
PR:000036135
TIRAP:PIP2:activated TLR4 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_152404
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
PR:000036007
TIRAP:PIP2 complex (mouse)
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway PMID:11544529
PR:P58753-2
hTIRAP/iso:2
capable_of GO:0005546 phosphatidylinositol-4,5-bisphosphate binding PMID:24529375
PR:000037448
pTIRAP:PIP2:BTK:activated TLR4 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_125282
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282
PR:000027196
TIRAP:PIP2:activated TLR4 (mouse)
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:12447442
PR:000036014
TIRAP:PIP2 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_151450
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
PR:000027192
pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000027183
IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000037475
MYD88:TIRAP:activated TLR4 receptor (chicken)
located_in GO:0005886 plasma membrane Reactome:REACT_26615
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_25089
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25089
PR:000037447
TIRAP:PIP2:BTK:activated TLR4 complex (human)
capable_of GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882
located_in GO:0005886 plasma membrane Reactome:REACT_120882
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882
PR:000027174
MYD88s:TIRAP:activated TLR4 receptor (mouse)
participates_in GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)

PMID:12538665
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000027196 TIRAP:PIP2:activated TLR4 (mouse)

PMID:12447442
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000036007 TIRAP:PIP2 complex (mouse)

PMID:11544529
PR:000036014 TIRAP:PIP2 complex (human)

Reactome:REACT_25222
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)

Reactome:REACT_25222
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)

Reactome:REACT_25089
GO:0034142 toll-like receptor 4 signaling pathway PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)

Reactome:REACT_6894
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)

Reactome:REACT_25089
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000036014 TIRAP:PIP2 complex (human)

Reactome:REACT_151450
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)

Reactome:REACT_152404
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)

Reactome:REACT_26615

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