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Protein Ontology Report - NFKB1

PR:000001754 - http://purl.obolibrary.org/obo/PR_000001754
Ontology Information
PRO ID PR:000001754 Show OBO stanza / PAF
PRO name nuclear factor NF-kappa-B p105 subunit
Synonyms
PRO-short-label: NFKB1
EXACT: DNA-binding factor KBF1; EBP-1; NF-kappa-B1 p84/NF-kappa-B1 p98; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Definition A transcription factor NF-kappa-B subunit that is a translation product of the human NFKB1 gene or a 1:1 ortholog thereof. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. [PMID:15485931, PRO:JAN]
PRO Category gene
Parent PR:000001753 transcription factor NF-kappa-B subunit
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 3 organism-sequence 15
modification 5 organism-modification 4
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

NFKB1 forms found in complexes
NFKB1 Component Complexes
PR:000028540 mNFKBp50 PR:000028542 NF-kappaB p50/p65 complex (mouse)
PR:000035834 hNFKBp50 PR:000035835 NF-kappaB p50/p65 complex (human)
PR:P19838 hNFKB1 PR:000028444 NFKB p105:TPL2:ABIN2 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035834
hNFKBp50
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0034142 toll-like receptor 4 signaling pathway PR:000035834 hNFKBp50

Reactome:REACT_6894

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