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Protein Ontology Report - CHUK

PR:000001775 - http://purl.obolibrary.org/obo/PR_000001775
Ontology Information
PRO ID PR:000001775 Show OBO stanza / PAF
PRO name inhibitor of nuclear factor kappa-B kinase subunit alpha
Synonyms
PRO-short-label: CHUK
EXACT: I-kappa-B kinase 1; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IKK1; IkBKA; IkappaB kinase; NFKBIKA; TCF-16; conserved helix-loop-helix ubiquitous kinase; nuclear factor NF-kappa-B inhibitor kinase alpha; transcription factor 16
Gene-based: IKKA; TCF16
Definition An inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits that is a translation product of the human CHUK gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000001774 inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 4
modification 1 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

CHUK forms found in complexes
CHUK Component Complexes
PR:000026823 hCHUK/iso:1/Phos:1 PR:000035833 activated IkappaB kinase complex (human)
PR:000036121 mCHUK/iso:1/Phos:1 PR:000036119 activated IkappaB kinase complex (mouse)
PR:O15111 hCHUK PR:000026457 IkappaB kinase complex (human)
PR:O15111 hCHUK PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:O15111 hCHUK PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:Q60680-1 mCHUK/iso:1 PR:000036118 IkappaB kinase complex (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000026457
IkappaB kinase complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26016
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035833
activated IkappaB kinase complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034142 toll-like receptor 4 signaling pathway PR:000026457 IkappaB kinase complex (human)

Reactome:REACT_6894
PR:000035833 activated IkappaB kinase complex (human)

Reactome:REACT_6894
GO:0034138 toll-like receptor 3 signaling pathway PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26016
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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