Protein Ontology Report - IRAK3 PR:000001784 - http://purl.obolibrary.org/obo/PR_000001784

Ontology Information
PRO ID	PR:000001784 Show OBO stanza / PAF
PRO name	interleukin-1 receptor-associated kinase 3
Synonyms	PRO-short-label: EXACT: IRAK3 Other: EXACT: IL-1 receptor-associated kinase M | IRAK-3 | IRAK-M | inactive IL-1 receptor-associated kinase 3
Definition	An interleukin-1 receptor-associated kinase IRAK1/3 that is a translation product of the human IRAK3 gene or a 1:1 ortholog thereof. [PMID:12150927, PRO:CNA]
PRO Category	gene
Parent	PR:000001781 interleukin-1 receptor-associated kinase IRAK1/3
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Independent Organism-Specific Category Number of Terms Category Number of Terms gene 1 organism-gene 3 sequence 1 organism-sequence 4 modification 0 organism-modification 0 union 0
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	IUPHARobj:2044

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All gene organism-gene sequence organism-sequence
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

IRAK3 forms found in complexes
IRAK3 Component Complexes PR:Q8K4B2 mIRAK3 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)

Functional Annotation PRO Centric View GO Centric View
PRO Term GO Annotation Evidence PR:Q8K4B2 mIRAK3 acts_upstream_of_or_within GO:0034122 negative regulation of toll-like receptor signaling pathway PMID:12150927 PR:Q9Y616-1 hIRAK3/iso:1 acts_upstream_of_or_within GO:0034122 negative regulation of toll-like receptor signaling pathway PMID:10383454 enables GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:10383454

top