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Protein Ontology Report - MHCcIalpha

PR:000001818 - http://purl.obolibrary.org/obo/PR_000001818
Ontology Information
PRO ID PR:000001818 Show OBO stanza / PAF
PRO name MHC class I histocompatibility antigen alpha chain
Synonyms
PRO-short-label: MHCcIalpha
Definition A protein with core architecture consisting of an extracellular region with Class I Histocompatibility antigen, domains alpha 1 and alpha two (Pfam:PF00129) and an Immunoglobulin C1-set domain (Pfam:PF07654), a single-pass transmembrane region, and a cytoplasmic region containing the MHC_I C-terminus (Pfam:PF06623). [PRO:WCB, Wikipedia:Human_leukocyte_antigen]
Comment Note: There are three major and three minor class I MHC (major histocompatability complex) alpha chain genes in human. Designations for the MHC complex loci are species specific: HLA (human leukocyte antigen) in human, H-2 in mouse. MHC class I loci are characterized by large numbers of allelic variants. Human and mouse genes for MHC class I histocompatibility antigen alpha chains represent independent lineage-specific expansions. MHC class I histocompatibility antigen alpha chains associate with beta-2 microglobulin to form the heterodimeric MHC antigens.
PRO Category family
Parent PR:000000001 protein
Term Hierarchy Visualization DAG     OLS     Cytoscape

Functional Annotation
PRO Term GO Annotation Evidence
PR:000001818
MHCcIalpha
has_part Pfam:PF06623 MHC_I C-terminus
has_part Pfam:PF07654 Immunoglobulin C1-set domain
has_part Pfam:PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2

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