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||MHC class I histocompatibility antigen alpha chain
|| A protein with core architecture consisting of an extracellular region with Class I Histocompatibility antigen, domains alpha 1 and alpha two (Pfam:PF00129) and an Immunoglobulin C1-set domain (Pfam:PF07654), a single-pass transmembrane region, and a cytoplasmic region containing the MHC_I C-terminus (Pfam:PF06623).
||Note: There are three major and three minor class I MHC (major histocompatability complex) alpha chain genes in human. Designations for the MHC complex loci are species specific: HLA (human leukocyte antigen) in human, H-2 in mouse. MHC class I loci are characterized by large numbers of allelic variants. Human and mouse genes for MHC class I histocompatibility antigen alpha chains represent independent lineage-specific expansions. MHC class I histocompatibility antigen alpha chains associate with beta-2 microglobulin to form the heterodimeric MHC antigens.
|| PR:000000001 protein
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