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Protein Ontology Report - MHCcIIalpha

PR:000001820 -
Ontology Information
PRO ID PR:000001820 Show OBO stanza / PAF
PRO name MHC class II histocompatibility antigen alpha chain
PRO-short-label: MHCcIIalpha
Definition A protein with core architecture consisting of a signal sequence, a Class II histocompatibility antigen, alpha domain (Pfam:PF00993) and an Immunoglobulin C1-set domain (Pfam:PF07654); these form the extracellular domain and are followed by a single-pass transmembrane region and a small cytoplasmic region. [PRO:WCB, Wikipedia:Human_leukocyte_antigen]
Comment Note: There are three major and two minor class II MHC (major histocompatability complex) alpha chain genes in human. Designations for the MHC complex loci are species specific: HLA (human leukocyte antigen) in human, H-2 in mouse. MHC class II loci are characterized by large numbers of allelic variants. In contrast to MHC Class I alpha chain genes, orthologies can be seen between some human and mouse genes. MHC class II alpha chains form heterodimers with MHLC class II beta chains.
PRO Category family
Parent PR:000000001 protein
Term Hierarchy Visualization DAG     OLS     Cytoscape

Functional Annotation
PRO Term GO Annotation Evidence
has_part Pfam:PF07654 Immunoglobulin C1-set domain
has_part Pfam:PF00993 Class II histocompatibility antigen, alpha domain