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Protein Ontology Report - CD14

PR:000001889 - http://purl.obolibrary.org/obo/PR_000001889
Ontology Information
PRO ID PR:000001889 Show OBO stanza / PAF
PRO name CD14 molecule
Synonyms
PRO-short-label: CD14
EXACT: monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein
Definition A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof. [PRO:WCB]
Comment Requested by=CL.
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 1
modification 8 organism-modification 10
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

CD14 forms found in complexes
CD14 Component Complexes
PR:000001889 CD14 PR:000037465 LPS:CD14 complex
PR:000002147 CD14/iso:1/Clv:2/soluble PR:000025498 lipopolysaccharide receptor complex 4
PR:000002147 CD14/iso:1/Clv:2/soluble PR:000025496 lipopolysaccharide receptor complex 2
PR:000002149 CD14/iso:1/Clv:2/anchored PR:000025495 lipopolysaccharide receptor complex 1
PR:000002149 CD14/iso:1/Clv:2/anchored PR:000025493 LPS:GPI-anchored CD14 complex
PR:000002149 CD14/iso:1/Clv:2/anchored PR:000025497 lipopolysaccharide receptor complex 3
PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000035702 hCD14/iso:1/Clv:2/anchored PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000035703 hCD14/iso:1/Clv:2/soluble PR:000037463 LPS:secreted CD14 alpha (human)
PR:000035703 hCD14/iso:1/Clv:2/soluble PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000036849 CD14/iso:1/ClvPrd/soluble PR:000029989 LPS:secreted CD14 complex
PR:000036850 mCD14/iso:1/ClvPrd/soluble PR:000037467 LPS:secreted CD14 complex (mouse)
PR:000037470 mCD14/iso:1/Clv:2/anchored PR:000037468 LPS:GPI-anchored CD14 complex (mouse)
PR:000037470 mCD14/iso:1/Clv:2/anchored PR:000037476 lipopolysaccharide receptor complex 3 (mouse)
PR:000037480 hCD14/iso:1/Clv:2 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000037480 hCD14/iso:1/Clv:2 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037480 hCD14/iso:1/Clv:2 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037480 hCD14/iso:1/Clv:2 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:B0BL87 chick-CD14 PR:000037466 LPS:transmembrane CD14 complex (chicken)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035703
hCD14/iso:1/Clv:2/soluble
capable_of GO:0001530 lipopolysaccharide binding PMID:9464818
expressed_in CL:0000129 microglial cell PMID:24659539
located_in GO:0005576 extracellular region PMID:2779588, PMID:9665271
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000035702
hCD14/iso:1/Clv:2/anchored
Asn-345, MOD:00167
located_in GO:0005886 plasma membrane Reactome:REACT_7740
located_in GO:0005886 plasma membrane PMID:2779588, PMID:3385210, PMID:9665271
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:B0BL87
chick-CD14
located_in GO:0009986 cell surface PMID:18761368
located_in GO:0005886 plasma membrane PMID:18761368
PR:000036848
CD14/iso:1/Clv:2
located_in GO:0016020 membrane MGI:3836081, PMID:18854309
located_in GO:0005737 cytoplasm MGI:3836081, PMID:18854309
participates_in GO:0032147 activation of protein kinase activity MGI:3836081, PMID:18854309
PR:000025773
lipopolysaccharide receptor complex 3 (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000037448
pTIRAP:PIP2:BTK:activated TLR4 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_125282
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282
PR:000037469
mCD14/iso:1/Clv:1/soluble
expressed_in CL:0000129 microglial cell PMID:24659539
PR:000037464
LPS:GPI-anchored CD14 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_7856
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000037476
lipopolysaccharide receptor complex 3 (mouse)
participates_in GO:0034142 toll-like receptor 4 signaling pathway PMID:12196527
PR:000037466
LPS:transmembrane CD14 complex (chicken)
located_in GO:0009986 cell surface PMID:18761368, PMID:24034933
participates_in GO:0045429 positive regulation of nitric oxide biosynthetic process PMID:24034933
participates_in GO:0051607 defense response to virus PMID:24034933
PR:P10810
mCD14
expressed_in CL:0000127 astrocyte PMID:24659539
PR:000037447
TIRAP:PIP2:BTK:activated TLR4 complex (human)
capable_of GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882
located_in GO:0005886 plasma membrane Reactome:REACT_120882
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882
PR:000037463
LPS:secreted CD14 alpha (human)
located_in GO:0005615 extracellular space Reactome:REACT_7856
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000027208
ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_7861
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26016
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036135
TIRAP:PIP2:activated TLR4 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_152404
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
PR:000001889
CD14
has_part Pfam:PF00560 Leucine Rich Repeat
PR:000036615
hCD14/iso:1/Clv:1/soluble
located_in GO:0005576 extracellular region PMID:7519994
PR:P08571
hCD14
expressed_in NOT CL:0000127 astrocyte PMID:24659539
PR:000036022
traf3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004842 ubiquitin-protein transferase activity Reactome:REACT_124037
located_in GO:0010008 endosome membrane Reactome:REACT_124037
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_124037
PR:000028680
traf6:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_25948
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0045429 positive regulation of nitric oxide biosynthetic process PR:000037466 LPS:transmembrane CD14 complex (chicken)

PMID:24034933
GO:0051607 defense response to virus PR:000037466 LPS:transmembrane CD14 complex (chicken)

PMID:24034933
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)

Reactome:REACT_25222
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
GO:0034142 toll-like receptor 4 signaling pathway PR:000025773 lipopolysaccharide receptor complex 3 (human)

Reactome:REACT_6894
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035702 hCD14/iso:1/Clv:2/anchored
Asn-345, MOD:00167
Reactome:REACT_6894
PR:000035703 hCD14/iso:1/Clv:2/soluble

Reactome:REACT_6894
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
PR:000037463 LPS:secreted CD14 alpha (human)

Reactome:REACT_6894
PR:000037464 LPS:GPI-anchored CD14 complex (human)

Reactome:REACT_6894
PR:000037476 lipopolysaccharide receptor complex 3 (mouse)

PMID:12196527
GO:0032147 activation of protein kinase activity PR:000036848 CD14/iso:1/Clv:2

MGI:3836081, PMID:18854309
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0016020 membrane PR:000036848 CD14/iso:1/Clv:2

MGI:3836081, PMID:18854309
GO:0005737 cytoplasm PR:000036848 CD14/iso:1/Clv:2

MGI:3836081, PMID:18854309
GO:0005886 plasma membrane PR:000035702 hCD14/iso:1/Clv:2/anchored
Asn-345, MOD:00167
Reactome:REACT_7740
PR:000035702 hCD14/iso:1/Clv:2/anchored
Asn-345, MOD:00167
PMID:2779588, PMID:3385210, PMID:9665271
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)

Reactome:REACT_152404
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
PR:000037464 LPS:GPI-anchored CD14 complex (human)

Reactome:REACT_7856
PR:B0BL87 chick-CD14

PMID:18761368
GO:0005615 extracellular space PR:000037463 LPS:secreted CD14 alpha (human)

Reactome:REACT_7856
GO:0005576 extracellular region PR:000035703 hCD14/iso:1/Clv:2/soluble

PMID:2779588, PMID:9665271
PR:000036615 hCD14/iso:1/Clv:1/soluble

PMID:7519994
GO:0009986 cell surface PR:000037466 LPS:transmembrane CD14 complex (chicken)

PMID:18761368, PMID:24034933
PR:B0BL87 chick-CD14

PMID:18761368
GO:0010008 endosome membrane PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_7861
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_25948
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26016

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