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Protein Ontology Report - BTK

PR:000002110 - http://purl.obolibrary.org/obo/PR_000002110
Ontology Information
PRO ID PR:000002110 Show OBO stanza / PAF
PRO name tyrosine-protein kinase BTK
Synonyms
PRO-short-label: BTK
EXACT: ATK; B-cell progenitor kinase; BPK; agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; bruton tyrosine kinase; kinase EMB
Gene-based: AGMX1
Definition A TEC-type tyrosine-protein kinase that is a translation product of the human BTK gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000001967 TEC-type tyrosine-protein kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 3
modification 2 organism-modification 5
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

BTK forms found in complexes
BTK Component Complexes
PR:000044351 hBTK/InitMet- PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000044351 hBTK/InitMet- PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000044351 hBTK/InitMet- PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P35991 mBTK PR:000037478 pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:P35991 mBTK PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:P35991 mBTK PR:000037477 TIRAP:PIP2:BTK:activated TLR4 complex (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037448
pTIRAP:PIP2:BTK:activated TLR4 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_125282
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282
PR:000002110
BTK
has_part Pfam:PF00018 SH3 domain
has_part Pfam:PF00017 SH2 domain
has_part Pfam:PF00169 PH domain
has_part Pfam:PF07714 Protein tyrosine and serine/threonine kinase
has_part Pfam:PF00779 BTK motif
PR:000037447
TIRAP:PIP2:BTK:activated TLR4 complex (human)
capable_of GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882
located_in GO:0005886 plasma membrane Reactome:REACT_120882
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
GO:0034142 toll-like receptor 4 signaling pathway PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_120882
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)

Reactome:REACT_125282

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