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Protein Ontology Report - CTNNB1

PR:000002198 - http://purl.obolibrary.org/obo/PR_000002198
Ontology Information
PRO ID PR:000002198 Show OBO stanza / PAF
PRO name catenin beta-1
Synonyms
PRO-short-label: CTNNB1
EXACT: beta-catenin
Gene-based: CTNNB; Catnb; OK/SW-cl.35
Definition A protein that is a translation product of the human CTNNB1 gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 1 organism-sequence 4
modification 26 organism-modification 29
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037515
hCTNNB1/iso:1/Phos:11
Ser-33/Ser-37, MOD:00046
capable_of GO:0005515 protein binding increased relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 with PR:Q9Y297 hBTRC PMID:16996060, PMID:21152425, PMID:23071615
capable_of GO:0003713 transcription coactivator activity decreased relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
participates_in GO:0060070 canonical Wnt signaling pathway decreased relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
participates_in GO:0008283 cell proliferation decreased relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
PR:000044510
hCTNNB1/iso:1/Phos:14
Ser-552, MOD:00046
capable_of GO:0071889 14-3-3 protein binding with PR:P63104 hYWHAZ PMID:17287208
PR:000035772
hCTNNB1/iso:1/Phos:3
Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047
capable_of NOT GO:0005515 protein binding with PR:Q9UKB1 hFBXW11 PMID:10074433
capable_of GO:0005515 protein binding with PR:Q9Y297 hBTRC PMID:10074433
PR:000037187
mCTNNB1/Phos:2
Ser-29, MOD:00046|Thr-102/Thr-112, MOD:00047
capable_of GO:0045294 alpha-catenin binding PMID:12432063
capable_of GO:0019901 protein kinase binding increased relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 with PR:Q9WV60 mGSK3B PMID:12432063
located_in GO:0005913 cell-cell adherens junction PMID:12432063
PR:000035770
hCTNNB1/iso:1/Phos:2
located_in GO:0005634 nucleus PMID:20026641
PR:000030192
hCTNNB1/iso:1/Phos:1
Ser-663/Ser-675, MOD:00046
capable_of GO:0003713 transcription coactivator activity increased relative to PR:000002862 CTNNB1/iso:1/UnMod PMID:22369945
participates_in GO:0016055 Wnt signaling pathway PMID:22369945
PR:000035774
hCTNNB1/iso:1/Phos:4
Ser-45, MOD:00046
capable_of GO:0005515 protein binding increased relative to PR:000037813 hCTNNB1/iso:1/UnPhos:6 with PR:P49841 hGSK3B PMID:12051714, PMID:20419129, PMID:23606879
capable_of GO:0005515 protein binding with PR:P12830 hCDH1 PMID:20419129, PMID:21152425
located_in GO:0005634 nucleus PMID:20419129
PR:000036862
hCTNNB1/iso:1/Phos:5
Ser-552/Ser-675, MOD:00046
capable_of GO:0003713 transcription coactivator activity increased relative to PR:000036872 hCTNNB1/iso:1/UnPhos:1 PMID:16476742
capable_of GO:0005515 protein binding increased relative to PR:000036872 hCTNNB1/iso:1/UnPhos:1 with PR:Q92793 hCREBBP PMID:16476742
PR:000036860
mCTNNB1/Phos:1
Tyr-142, MOD:00048
capable_of GO:0045296 cadherin binding decreased relative to PR:000037183 mCTNNB1/UnPhos:1 PMID:12640114
PR:000037190
hCTNNB1/iso:1/Phos:7
Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047
capable_of GO:0005515 protein binding decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 with PR:Q9NQB0 hTCF7L2 PMID:23617586
capable_of GO:0005515 protein binding decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 with PR:P36402 hTCF7 PMID:23617586
capable_of GO:0003713 transcription coactivator activity decreased relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 PMID:20419129
capable_of NOT GO:0005515 protein binding with PR:P12830 hCDH1 PMID:21152425
capable_of GO:0005515 protein binding decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 with PR:Q9HCS4 hTCF7L1 PMID:23617586
capable_of GO:0005515 protein binding increased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 with PR:Q9Y297 hBTRC PMID:21152425
capable_of GO:0005515 protein binding decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 with PR:Q9UJU2 hLEF1 PMID:23617586
located_in GO:0005737 cytoplasm PMID:20419129
located_in GO:0005913 cell-cell adherens junction decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
participates_in GO:0007155 cell adhesion decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
participates_in GO:0010631 epithelial cell migration PMID:21152425
participates_in GO:0034333 adherens junction assembly decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
PR:000037192
hCTNNB1/iso:1/Phos:8
Tyr-333, MOD:00048
capable_of GO:0005515 protein binding with PR:P14618 hPKM PMID:22056988
capable_of GO:0003713 transcription coactivator activity PMID:22056988
located_in GO:0005634 nucleus PMID:22056988
participates_in GO:0007173 epidermal growth factor receptor signaling pathway PMID:22056988
PR:000037194
hCTNNB1/iso:1/Phos:9
Tyr-86/Tyr-654, MOD:00048
capable_of GO:0017025 TBP-class protein binding increased relative to PR:000037196 hCTNNB1/iso:1/UnPhos:3 with PR:P20226 hTBP PMID:11279024
capable_of GO:0045296 cadherin binding decreased relative to PR:000037196 hCTNNB1/iso:1/UnPhos:3 with PR:P12830 hCDH1 PMID:11279024
PR:000037185
hCTNNB1/iso:1/UnPhos:2
Ser-37/Thr-41, PR:000026291
capable_of GO:0005515 protein binding with PR:P12830 hCDH1 PMID:20419129
capable_of GO:0003713 transcription coactivator activity PMID:20419129
located_in GO:0005634 nucleus PMID:20419129
PR:000044474
hCTNNB1/iso:1/Phos:12
Thr-393, MOD:00047
capable_of GO:0005515 protein binding decreased relative to PR:000044476 hCTNNB1/iso:1/UnPhos:7 with PR:Q9YGY0 frog-axin PMID:19565571
participates_in GO:0016055 Wnt signaling pathway PMID:12700239
participates_in GO:0045944 positive regulation of transcription by RNA polymerase II PMID:12700239
PR:000044476
hCTNNB1/iso:1/UnPhos:7
Thr-393, PR:000026291
capable_of GO:0005515 protein binding with PR:Q9YGY0 frog-axin PMID:19565571
PR:000044478
hCTNNB1/iso:1/Phos:13
Tyr-654, MOD:00048
capable_of GO:0003713 transcription coactivator activity PMID:23640056
PR:000037181
hCTNNB1/iso:1/Phos:6
Ser-37, MOD:00046|Thr-41, MOD:00047
located_in GO:0005913 cell-cell adherens junction decreased relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 PMID:19667122
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007155 cell adhesion PR:000037190 hCTNNB1/iso:1/Phos:7
Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047
decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5
PMID:19667122
GO:0008283 cell proliferation PR:000037515 hCTNNB1/iso:1/Phos:11
Ser-33/Ser-37, MOD:00046
decreased relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4
PMID:20307497
GO:0060070 canonical Wnt signaling pathway PR:000037515 hCTNNB1/iso:1/Phos:11
Ser-33/Ser-37, MOD:00046
decreased relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4
PMID:20307497
GO:0034333 adherens junction assembly PR:000037190 hCTNNB1/iso:1/Phos:7
Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047
decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5
PMID:19667122
GO:0045944 positive regulation of transcription by RNA polymerase II PR:000044474 hCTNNB1/iso:1/Phos:12
Thr-393, MOD:00047
PMID:12700239
GO:0016055 Wnt signaling pathway PR:000030192 hCTNNB1/iso:1/Phos:1
Ser-663/Ser-675, MOD:00046
PMID:22369945
PR:000044474 hCTNNB1/iso:1/Phos:12
Thr-393, MOD:00047
PMID:12700239
GO:0010631 epithelial cell migration PR:000037190 hCTNNB1/iso:1/Phos:7
Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047
PMID:21152425
GO:0007173 epidermal growth factor receptor signaling pathway PR:000037192 hCTNNB1/iso:1/Phos:8
Tyr-333, MOD:00048
PMID:22056988
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000035770 hCTNNB1/iso:1/Phos:2

PMID:20026641
PR:000035774 hCTNNB1/iso:1/Phos:4
Ser-45, MOD:00046
PMID:20419129
PR:000037185 hCTNNB1/iso:1/UnPhos:2
Ser-37/Thr-41, PR:000026291
PMID:20419129
PR:000037192 hCTNNB1/iso:1/Phos:8
Tyr-333, MOD:00048
PMID:22056988
GO:0005737 cytoplasm PR:000037190 hCTNNB1/iso:1/Phos:7
Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047
PMID:20419129
GO:0005913 cell-cell adherens junction PR:000037181 hCTNNB1/iso:1/Phos:6
Ser-37, MOD:00046|Thr-41, MOD:00047
decreased relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2
PMID:19667122
PR:000037187 mCTNNB1/Phos:2
Ser-29, MOD:00046|Thr-102/Thr-112, MOD:00047
PMID:12432063
PR:000037190 hCTNNB1/iso:1/Phos:7
Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047
decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5
PMID:19667122

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