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Protein Ontology Report - APC

PR:000004122 -
Ontology Information
PRO ID PR:000004122 Show OBO stanza / PAF
PRO name adenomatous polyposis coli protein
PRO-short-label: APC
EXACT: deleted in polyposis 2.5; protein APC
Gene-based: DP2.5
Definition A protein that is a translation product of the human APC gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 0 organism-sequence 7
modification 5 organism-modification 8
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

APC forms found in complexes
APC Component Complexes
PR:000035395 frog-APC/Phos:6 PR:000035398 BUB1B:APC:EB1 complex (frog)
PR:P25054 hAPC PR:000035576 BUB1:BUB3:APC complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
capable_of GO:0005515 protein binding with PR:Q13257 hMAD2L1 BioGRID:BG-302957
capable_of GO:0008017 microtubule binding PMID:11283619
capable_of GO:0005515 protein binding with PR:O14641 hDVL2 PMID:20823832
capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:11283619
capable_of GO:0005515 protein binding with PR:O43684 hBUB3 PMID:11283619
located_in GO:0000776 kinetochore PMID:11283619
participates_in NOT GO:0031577 spindle checkpoint PMID:11283619
participates_in GO:0007059 chromosome segregation PMID:11283619
BUB1B:APC:EB1 complex (frog)
participates_in GO:0051310 metaphase plate congression PMID:17709426
Biological Process GO Term Protein Forms & Complexes Evidence
NOT GO:0031577 spindle checkpoint PR:P25054 hAPC

GO:0051310 metaphase plate congression PR:000035398 BUB1B:APC:EB1 complex (frog)

GO:0007059 chromosome segregation PR:P25054 hAPC

Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:P25054 hAPC