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Protein Ontology Report - AURKB

PR:000004517 - http://purl.obolibrary.org/obo/PR_000004517
Ontology Information
PRO ID PR:000004517 Show OBO stanza / PAF
PRO name aurora kinase B
Synonyms
PRO-short-label: AURKB
EXACT: AIM-1; ARK-2; aurora 1; aurora- and Ipl1-like midbody-associated protein 1; aurora-related kinase 2; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B
Gene-based: AIK2; AIM1; AIRK2; ARK2; STK12
RELATED: STK-1; Stk1; Stk5
Definition An aurora kinase that is a translation product of the human AURKB gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000035365 aurora kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 6
sequence 0 organism-sequence 5
modification 3 organism-modification 4
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035661
hAURKB/PhosRes-
capable_of GO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:22024163
located_in GO:0000776 kinetochore PMID:22024163
PR:Q96GD4
hAURKB
capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 BioGRID:BG-684898
capable_of GO:0005515 protein binding with PR:Q53HL2 hCDCA8 BioGRID:BG-251030
capable_of GO:0005515 protein binding with PR:Q71DI3 hH3.2 BioGRID:BG-725715
capable_of GO:0005515 protein binding with PR:Q15208 hSTK38 PMID:20171103
capable_of GO:0005515 protein binding with PR:O15392 hBIRC5 BioGRID:BG-571501, IntAct:EBI-979359, MINT:MINT-4509558
capable_of GO:0005515 protein binding with PR:Q13043 hSTK4 PMID:20171103
capable_of GO:0005515 protein binding with PR:P06493 hCDK1 IntAct:EBI-1397755
capable_of GO:0005515 protein binding with PR:P68431 hH3.1 BioGRID:BG-530650
capable_of GO:0005515 protein binding with PR:Q9NQS7 hINCENP BioGRID:BG-251075, IntAct:EBI-1555366, MINT:MINT-77928
capable_of GO:0004672 protein kinase activity PMID:12719470
capable_of GO:0005515 protein binding with PR:O60566 hBUB1B BioGRID:BG-717913
located_in GO:0000779 condensed chromosome, centromeric region PMID:12719470, PMID:15917996
located_in GO:0000776 kinetochore PMID:20624902
located_in GO:0000939 condensed chromosome inner kinetochore PMID:15592459
located_in GO:0030496 midbody PMID:15917996
located_in GO:0051233 spindle midzone PMID:15917996
participates_in GO:0008608 attachment of spindle microtubules to kinetochore PMID:12719470, PMID:15592459
participates_in GO:0031577 spindle checkpoint PMID:12719470
participates_in GO:0140014 mitotic nuclear division PMID:12719470
participates_in GO:0051310 metaphase plate congression PMID:12719470, PMID:22732840
participates_in GO:0071459 protein localization to chromosome, centromeric region PMID:12719470, PMID:21658950
participates_in GO:0007059 chromosome segregation PMID:12719470
participates_in GO:0034501 protein localization to kinetochore PMID:12719470, PMID:17617734, PMID:22732840
participates_in NOT GO:0051306 mitotic sister chromatid separation PMID:12719470
PR:000035663
hAURKB/Phos:1
Ser-331, MOD:00046
capable_of GO:0004672 protein kinase activity increased relative to PR:000035661 hAURKB/PhosRes- PMID:17276342, PMID:22024163
capable_of GO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:22024163
located_in GO:0000776 kinetochore PMID:22024163
participates_in GO:0031577 spindle checkpoint increased relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
participates_in GO:0007059 chromosome segregation increased relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
participates_in GO:0051310 metaphase plate congression increased relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0071459 protein localization to chromosome, centromeric region PR:Q96GD4 hAURKB

PMID:12719470, PMID:21658950
NOT GO:0051306 mitotic sister chromatid separation PR:Q96GD4 hAURKB

PMID:12719470
GO:0007059 chromosome segregation PR:000035663 hAURKB/Phos:1
Ser-331, MOD:00046
increased relative to PR:000035661 hAURKB/PhosRes-
PMID:22024163
PR:Q96GD4 hAURKB

PMID:12719470
GO:0008608 attachment of spindle microtubules to kinetochore PR:Q96GD4 hAURKB

PMID:12719470, PMID:15592459
GO:0034501 protein localization to kinetochore PR:Q96GD4 hAURKB

PMID:12719470, PMID:17617734, PMID:22732840
GO:0031577 spindle checkpoint PR:000035663 hAURKB/Phos:1
Ser-331, MOD:00046
increased relative to PR:000035661 hAURKB/PhosRes-
PMID:22024163
PR:Q96GD4 hAURKB

PMID:12719470
GO:0051310 metaphase plate congression PR:000035663 hAURKB/Phos:1
Ser-331, MOD:00046
increased relative to PR:000035661 hAURKB/PhosRes-
PMID:22024163
PR:Q96GD4 hAURKB

PMID:12719470, PMID:22732840
GO:0140014 mitotic nuclear division PR:Q96GD4 hAURKB

PMID:12719470
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000779 condensed chromosome, centromeric region PR:Q96GD4 hAURKB

PMID:12719470, PMID:15917996
GO:0030496 midbody PR:Q96GD4 hAURKB

PMID:15917996
GO:0000939 condensed chromosome inner kinetochore PR:Q96GD4 hAURKB

PMID:15592459
GO:0000776 kinetochore PR:000035661 hAURKB/PhosRes-

PMID:22024163
PR:000035663 hAURKB/Phos:1
Ser-331, MOD:00046
PMID:22024163
PR:Q96GD4 hAURKB

PMID:20624902
GO:0051233 spindle midzone PR:Q96GD4 hAURKB

PMID:15917996

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