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Protein Ontology Report - SPTLC2

PR:000015597 - http://purl.obolibrary.org/obo/PR_000015597
Ontology Information
PRO ID PR:000015597 Show OBO stanza / PAF
PRO name serine palmitoyltransferase 2
Synonyms
PRO-short-label: EXACT: SPTLC2
Gene-based: RELATED: KIAA0526 | LCB2
Other: EXACT: LCB 2 | LCB2a | SPT 2 | long chain base biosynthesis protein 2 | long chain base biosynthesis protein 2a | serine-palmitoyl-CoA transferase 2
Definition A eukaryotic serine palmitoyltransferase that is a translation product of the human SPTLC2 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000026126 eukaryotic serine palmitoyltransferase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 2
modification 0 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

SPTLC2 forms found in complexes
SPTLC2 Component Complexes
PR:O15270 hSPTLC2 PR:000026155 serine palmitoyltransferase complex A (human)
PR:O15270 hSPTLC2 PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:O15270 hSPTLC2 PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:O15270 hSPTLC2 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:P97363 mSPTLC2 PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:P97363 mSPTLC2 PR:000025761 serine palmitoyltransferase complex (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000026144
serine palmitoyltransferase complex core 1 (human)
enables GO:0004758 serine C-palmitoyltransferase activity PMID:19416851
PR:P97363
mSPTLC2
acts_upstream_of_or_within GO:0046513 ceramide biosynthetic process PMID:16216550
acts_upstream_of_or_within GO:0006686 sphingomyelin biosynthetic process PMID:16216550
acts_upstream_of_or_within GO:0046512 sphingosine biosynthetic process PMID:16216550
PR:000026153
serine palmitoyltransferase complex 5 (human)
enables GO:0004758 serine C-palmitoyltransferase activity increased relative to PR:000026144 serine palmitoyltransferase complex core 1 (human) PMID:19416851
PR:000026154
serine palmitoyltransferase complex 6 (human)
enables GO:0004758 serine C-palmitoyltransferase activity increased relative to PR:000026144 serine palmitoyltransferase complex core 1 (human) PMID:19416851
PR:P97363-1
mSPTLC2/iso:1
acts_upstream_of_or_within GO:0046511 sphinganine biosynthetic process PMID:9363775
enables GO:0004758 serine C-palmitoyltransferase activity PMID:9363775
located_in GO:0005739 mitochondrion PMID:18614015
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005739 mitochondrion PR:P97363-1 mSPTLC2/iso:1

PMID:18614015

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