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Protein Ontology Report - STK11

PR:000015740 - http://purl.obolibrary.org/obo/PR_000015740
Ontology Information
PRO ID PR:000015740 Show OBO stanza / PAF
PRO name serine/threonine-protein kinase STK11
Synonyms
PRO-short-label: STK11
EXACT: renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase LKB1
Gene-based: LKB1; PJS
Definition A protein that is a translation product of the human STK11 gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 8
sequence 2 organism-sequence 9
modification 3 organism-modification 6
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

STK11 forms found in complexes
STK11 Component Complexes
PR:Q9WTK7-1 mSTK11/iso:1 PR:000025037 Stk11 isoform 1:Strada:Cab39 heterotrimer (mouse)
PR:Q9WTK7-2 mSTK11/iso:2 PR:000025038 Stk11 isoform 2:Strada:Cab39 heterotrimer (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036997
mSTK11/iso:1/UnPhos:1
Tyr-261/Tyr-365, PR:000026291
located_in GO:0005737 cytoplasm MGI:4439241, PMID:20142099
PR:000036893
mSTK11/iso:1/Phos:1
Tyr-261/Tyr-365, MOD:00048
located_in GO:0005634 nucleus MGI:4439241, PMID:20142099
PR:000036995
mSTK11/iso:1/Phos:2
Tyr-36/Tyr-261/Tyr-365, MOD:00048
located_in GO:0036398 TCR signalosome MGI:5003385, PMID:21487392
participates_in GO:0036399 TCR signalosome assembly MGI:5003385, PMID:21487392
participates_in GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI:5003385, PMID:21487392
PR:000036994
STK11/iso:1/Phos:2
Tyr-36/Tyr-261/Tyr-365, MOD:00048
located_in GO:0036398 TCR signalosome MGI:5003385, PMID:21487392
participates_in GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI:5003385, PMID:21487392
participates_in GO:0036399 TCR signalosome assembly MGI:5003385, PMID:21487392
PR:Q9WTK7-1
mSTK11/iso:1
located_in GO:0005737 cytoplasm MGI:3836081, PMID:18854309
located_in GO:0016020 membrane MGI:3836081, PMID:18854309
participates_in GO:0032147 activation of protein kinase activity MGI:3836081, PMID:18854309
PR:Q9WTK7-2
mSTK11/iso:2
located_in GO:0005737 cytoplasm MGI:3836081, PMID:18854309
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation PR:000036994 STK11/iso:1/Phos:2
Tyr-36/Tyr-261/Tyr-365, MOD:00048
MGI:5003385, PMID:21487392
PR:000036995 mSTK11/iso:1/Phos:2
Tyr-36/Tyr-261/Tyr-365, MOD:00048
MGI:5003385, PMID:21487392
GO:0036399 TCR signalosome assembly PR:000036994 STK11/iso:1/Phos:2
Tyr-36/Tyr-261/Tyr-365, MOD:00048
MGI:5003385, PMID:21487392
PR:000036995 mSTK11/iso:1/Phos:2
Tyr-36/Tyr-261/Tyr-365, MOD:00048
MGI:5003385, PMID:21487392
GO:0032147 activation of protein kinase activity PR:Q9WTK7-1 mSTK11/iso:1

MGI:3836081, PMID:18854309
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0016020 membrane PR:Q9WTK7-1 mSTK11/iso:1

MGI:3836081, PMID:18854309
GO:0005634 nucleus PR:000036893 mSTK11/iso:1/Phos:1
Tyr-261/Tyr-365, MOD:00048
MGI:4439241, PMID:20142099
GO:0005737 cytoplasm PR:000036997 mSTK11/iso:1/UnPhos:1
Tyr-261/Tyr-365, PR:000026291
MGI:4439241, PMID:20142099
PR:Q9WTK7-1 mSTK11/iso:1

MGI:3836081, PMID:18854309
PR:Q9WTK7-2 mSTK11/iso:2

MGI:3836081, PMID:18854309
GO:0036398 TCR signalosome PR:000036994 STK11/iso:1/Phos:2
Tyr-36/Tyr-261/Tyr-365, MOD:00048
MGI:5003385, PMID:21487392
PR:000036995 mSTK11/iso:1/Phos:2
Tyr-36/Tyr-261/Tyr-365, MOD:00048
MGI:5003385, PMID:21487392

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