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Protein Ontology Report - LPSR:3

PR:000025497 - http://purl.obolibrary.org/obo/PR_000025497
Ontology Information
PRO ID PR:000025497 Show OBO stanza / PAF
PRO name lipopolysaccharide receptor complex 3
Synonyms
PRO-short-label: LPSR:3
Definition A lipopolysaccharide receptor complex that contains the membrane bound form of CD14, and the lipopolysaccharide (LPS) bound to LY96(MD-2). [PMID:7539760, PMID:9464818]
PRO Category complex
Parent GO:0046696 lipopolysaccharide receptor complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 4
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037476 PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA] 2
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA] 2
PR:000037470 CD14 molecule isoform 1 cleaved 2 GPI-anchored form (mouse) mCD14/iso:1/Clv:2/anchored A CD14 molecule isoform 1 cleaved 2 GPI-anchored form in mouse. UniProtKB:P10810-1, 16-336, Asn-336, MOD:00167. [PMID:10601848, PMID:18606699, PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
PR:000025773 PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM] 2
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] 2
PR:000035702 CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human) hCD14/iso:1/Clv:2/anchored A CD14 molecule isoform 1 cleaved 2 GPI-anchored form in human. UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167. [Reactome:R-HSA-166033, Reactome:R-HSA-2201284] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2
PR:000025497 PR:000003299 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 LY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form that has been N-glycosylated at positions equivalent to Asn-26 and Asn-114 of the amino acid sequence represented by UniProtKB:Q9Y6Y9-1. Example: UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:17569869, PRO:CNA, PRO:DAN, TLR:AMM]
PR:000025492 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 TLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1 that is the mature N-glycosylated form. Example: UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480]
PR:000002149 CD14 molecule isoform 1 cleaved 2 GPI-anchored form CD14/iso:1/Clv:2/anchored A CD14 molecule isoform 1 cleaved 2 that is the mature membrane-bound form of this protein. Example: UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167. [PMID:3385210, PRO:CNA]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037476
lipopolysaccharide receptor complex 3 (mouse)
participates_in GO:0034142 toll-like receptor 4 signaling pathway PMID:12196527
PR:000036137
lipopolysaccharide receptor complex 3; endosome membrane (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6894
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036136
lipopolysaccharide receptor complex 3; plasma membrane (human)
located_in GO:0005886 plasma membrane Reactome:REACT_6894
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_6894
PR:000025773
lipopolysaccharide receptor complex 3 (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036137 lipopolysaccharide receptor complex 3; endosome membrane (human)

Reactome:REACT_6809
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000036136 lipopolysaccharide receptor complex 3; plasma membrane (human)

Reactome:REACT_6894
GO:0034142 toll-like receptor 4 signaling pathway PR:000025773 lipopolysaccharide receptor complex 3 (human)

Reactome:REACT_6894
PR:000037476 lipopolysaccharide receptor complex 3 (mouse)

PMID:12196527
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000036136 lipopolysaccharide receptor complex 3; plasma membrane (human)

Reactome:REACT_6894
GO:0010008 endosome membrane PR:000036137 lipopolysaccharide receptor complex 3; endosome membrane (human)

Reactome:REACT_6894

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