back to PRO homepage
  Home |   Browse |   Search |   SPARQL |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Wiki
 PRO Consortium
 Publications
 Documentation

Protein Ontology Report - (SMAD2:SMAD4):1

PR:000025967 - http://purl.obolibrary.org/obo/PR_000025967
Ontology Information
PRO ID PR:000025967 Show OBO stanza / PAF
PRO name smad2-smad4 protein complex 1
Synonyms
PRO-short-label: (SMAD2:SMAD4):1
Definition A smad2-smad4 protein complex that contains smad4 and the long isoform of smad2 phosphorylated in the last two Ser residues within the SSxS C-terminal motif. [PMID:15350224]
PRO Category complex
Parent GO:0071144 heteromeric SMAD protein complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 2
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000025944 PR:P97471-1 mothers against decapentaplegic homolog 4 isoform 1 (mouse) mSMAD4/iso:1 A smad4 isoform 1 that is encoded in the genome of mouse. [PRO:CNA] 1
PR:000025942 smad2 isoform Long phosphorylated 1 (mouse) mSMAD2/iso:Long/Phos:1 A smad2 isoform Long phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046. [PMID:8980228, PMID:9346966] 2
PR:000025933 PR:Q13485 mothers against decapentaplegic homolog 4 (human) hSMAD4 A smad4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13485] 1
PR:000025934 smad2 isoform Long phosphorylated 1 (human) hSMAD2/iso:Long/Phos:1 A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046. [PMID:8980228, PMID:9346966] 2
PR:000025967 PR:000000366 smad4 isoform 1 SMAD4/iso:1 A smad4 that is a translation product of a mature transcript of the SMAD4 gene, and that contains the MH1 domain and the MH2 domain. Example: UniProtKB:Q13485-1. [PRO:CNA] 1
PR:000000650 smad2 isoform Long phosphorylated 1 SMAD2/iso:Long/Phos:1 A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. Example: UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046. [PMID:8980228, PMID:9346966] 2


Functional Annotation
PRO Term GO Annotation Evidence
PR:000025944
smad2-smad4 protein complex 1 (mouse)
located_in GO:0005634 nucleus PMID:12672795
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12672795
PR:000025933
smad2-smad4 protein complex 1 (human)
located_in GO:0005829 cytosol Reactome:REACT_7344
located_in GO:0005654 nucleoplasm Reactome:REACT_7382
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209, PMID:8980228
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000025933 smad2-smad4 protein complex 1 (human)

PMID:8752209, PMID:8980228
PR:000025944 smad2-smad4 protein complex 1 (mouse)

PMID:12672795
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000025933 smad2-smad4 protein complex 1 (human)

Reactome:REACT_7344
GO:0005654 nucleoplasm PR:000025933 smad2-smad4 protein complex 1 (human)

Reactome:REACT_7382
GO:0005634 nucleus PR:000025944 smad2-smad4 protein complex 1 (mouse)

PMID:12672795

top