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Protein Ontology Report - (SMAD2:SMAD4):3

PR:000025969 - http://purl.obolibrary.org/obo/PR_000025969
Ontology Information
PRO ID PR:000025969 Show OBO stanza / PAF
PRO name smad2-smad4 protein complex 3
Synonyms
PRO-short-label: (SMAD2:SMAD4):3
Definition A smad2-smad4 protein complex that contains smad4 and the long isoform of SMAD2 phosphorylated by ERK1. [PMID:12193595]
PRO Category complex
Parent GO:0071144 heteromeric SMAD protein complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000025946 PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 A smad4 isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:000025935 smad2 isoform Long phosphorylated 2 (human) hSMAD2/iso:Long/Phos:2 A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046. [PMID:12193595]
PR:000025969 PR:000000366 smad4 isoform 1 SMAD4/iso:1 A smad4 that is a translation product of a mature transcript of the SMAD4 gene, and that contains the MH1 domain and the MH2 domain. Example: UniProtKB:Q13485-1. [PRO:CNA]
PR:000000651 smad2 isoform Long phosphorylated 2 SMAD2/iso:Long/Phos:2 A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and multiple Ser and/or Thr residues in the linker region by ERK1. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046. [PMID:12193595]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000025946
smad2-smad4 protein complex 3 (human)
located_in GO:0005634 nucleus PMID:12193595
participates_in GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway PMID:12193595
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway PR:000025946 smad2-smad4 protein complex 3 (human)

PMID:12193595
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000025946 smad2-smad4 protein complex 3 (human)

PMID:12193595

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