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Protein Ontology Report - smad2-smad4-ski protein complex 1

PR:000025971 - http://purl.obolibrary.org/obo/PR_000025971
Ontology Information
PRO ID PR:000025971 Show OBO stanza / PAF
PRO name smad2-smad4-ski protein complex 1
Definition A smad2-smad4-ski protein complex with phosphorylated smad2. [PRO:CNA]
PRO Category complex
Parent PR:000025950 smad2-smad4-ski protein complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000025971 PR:000000366 smad4 isoform 1 SMAD4/iso:1 A smad4 that is a translation product of a mature transcript of the SMAD4 gene, and that contains the MH1 domain and the MH2 domain. Example: UniProtKB:Q13485-1. [PRO:CNA]
PR:000000650 smad2 isoform Long phosphorylated 1 SMAD2/iso:Long/Phos:1 A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. Example: UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046. [PMID:8980228, PMID:9346966]
PR:000025948 ski oncogene isoform 1 SKI/iso:1 A ski oncogene that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P12755-1 or a 1:1 ortholog thereof. [PMID:2762147, PRO:CNA]
PR:000025951 PR:P12755-1 ski oncogene isoform 1 (human) hSKI/iso:1 A ski oncogene isoform 1 that is encoded in the genome of human. [PMID:2762147, PRO:CNA]
PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human) hSMAD4/iso:1 A smad4 isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:000025934 smad2 isoform Long phosphorylated 1 (human) hSMAD2/iso:Long/Phos:1 A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046. [PMID:8980228, PMID:9346966]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000025951
smad2-smad4-ski protein complex 1 (human)
located_in GO:0005634 nucleus PMID:10485843
participates_in GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:10485843
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PR:000025951 smad2-smad4-ski protein complex 1 (human)

PMID:10485843
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000025951 smad2-smad4-ski protein complex 1 (human)

PMID:10485843

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