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Protein Ontology Report - TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)

PR:000028432 - http://purl.obolibrary.org/obo/PR_000028432
Ontology Information
PRO ID PR:000028432 Show OBO stanza
PRO name TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
Definition A death-inducing signaling complex that is composed of TNF receptor-associated factor 2, initiator methionine removed form (human), tumor necrosis factor (human), receptor-interacting serine/threonine-protein kinase 1 (human), tumor necrosis factor receptor type 1-associated DEATH domain protein (human), and tumor necrosis factor receptor superfamily member 1A, signal peptide removed form (human). [PRO:DAN, PRO:PDE, Reactome:R-HSA-140946]
Comment Note: The Reactome entry is itself a union of two versions of the complex, one containing TNF(77-233) and the other containing TNF(1-233).
PRO Category organism-complex
Parent GO:0031264 death-inducing signaling complex
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape


Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000028432 PR:Q15628 tumor necrosis factor receptor type 1-associated DEATH domain protein (human) hTRADD A tumor necrosis factor receptor type 1-associated DEATH domain protein that is encoded in the genome of human. [PRO:DNx] 3
PR:P01375 tumor necrosis factor (human) hTNF A tumor necrosis factor that is encoded in the genome of human. [PRO:DNx] 3
PR:Q13546 receptor-interacting serine/threonine-protein kinase 1 (human) hRIPK1 A receptor-interacting serine/threonine-protein kinase 1 that is encoded in the genome of human. [PRO:DNx] 1
PR:000028386 tumor necrosis factor receptor superfamily member 1A, signal peptide removed form (human) hTNFRSF1A/SigPep- A tumor necrosis factor receptor superfamily member 1A, signal peptide removed form in human. Example: UniProtKB:P19438-1, 22-455. [PRO:DNx] 3
PR:000028382 TNF receptor-associated factor 2, initiator methionine removed form (human) hTRAF2/InitMet- A TNF receptor-associated factor 2, initiator methionine removed form in human. Example: UniProtKB:Q12933-1, 2-501. [PRO:DNx] 3


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