Protein Ontology Report - hCTNNB1/iso:1/Phos:1 PR:000030192 - http://purl.obolibrary.org/obo/PR_000030192

Ontology Information
PRO ID	PR:000030192 Show OBO stanza / PAF / GPI
PRO name	catenin beta-1 isoform 1 phosphorylated 1 (human)
Synonyms	PRO-short-label: EXACT: hCTNNB1/iso:1/Phos:1 PRO-proteoform-std: EXACT: UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046
Definition	A catenin beta-1 isoform 1 phosphorylated 1 in human. Phosphorylation at Ser-663 is found in many human colon cancer cells and tissues, which display a high PAK1 activity, or in response to Wnt3a stimulation. Ser-675 can be phosphorylated by either PAK1 or PKA. UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046. [PMID:22369945, PRO:IC]
Comment	Kinase=("PAK1"; PR:000035776). Kinase=("PKA"; PR:000029188).
PRO Category	organism-modification
Parent	PR:000030191 catenin beta-1 isoform 1 phosphorylated 1
Taxon	NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization	DAG     OLS     Cytoscape

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PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View
PRO Term GO Annotation Evidence PR:000030192 hCTNNB1/iso:1/Phos:1 Ser-663/Ser-675, MOD:00046 acts_upstream_of_or_within GO:0016055 Wnt signaling pathway PMID:22369945 enables GO:0003713 transcription coactivator activity increased relative to PR:000002862 CTNNB1/iso:1/UnMod PMID:22369945

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