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Protein Ontology Report - frog-BUB1/Phos:3

PR:000035404 - http://purl.obolibrary.org/obo/PR_000035404
Ontology Information
PRO ID PR:000035404 Show OBO stanza / PAF / GPI
PRO name mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog)
Synonyms
PRO-short-label: EXACT: frog-BUB1/Phos:3
PRO-proteoform-std: EXACT: UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046
Other: RELATED: xBUB1 hyperphosphorylated
Definition A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 in frog. UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047, Ser-500/Ser-634, MOD:00046. [PMID:15241477, PRO:KER]
Comment Phosphorylation at Ser-500 is the most critical for checkpoint function. This form is observed during spindle disruption (nocodazole). Kinase=("MAPK"; PR:000000019).
PRO Category organism-modification
Parent PR:000035403 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3
Taxon NCBITaxon:8355 Xenopus laevis
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035404
frog-BUB1/Phos:3
Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046
acts_upstream_of_or_within GO:0031577 spindle checkpoint signaling PMID:15241477
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:15241477
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:15241477
acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:15241477
enables GO:0004672 protein kinase activity increased relative to PR:000029917 frog-BUB1/PhosRes- PMID:15241477

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