Protein Ontology Report - hBUB1/Phos:7 PR:000035412 - http://purl.obolibrary.org/obo/PR_000035412

Ontology Information
PRO ID	PR:000035412 Show OBO stanza / PAF / GPI
PRO name	mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human)
Synonyms	PRO-short-label: EXACT: hBUB1/Phos:7 PRO-proteoform-std: NARROW: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047
Definition	A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046, Thr-609, MOD:00047. [PMID:16760428, PRO:KER]
Comment	Kinase=("CDK1"; PR:000003271).
PRO Category	organism-modification
Parent	PR:000035413 BUB1 CDK-consensus sites phosphorylated form
Taxon	NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization	DAG     OLS     Cytoscape

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PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hBUB1/Phos:7 forms found in complexes
hBUB1/Phos:7 Component Complexes PR:000035412 hBUB1/Phos:7 PR:000035581 phosphoBUB1:PLK1 complex (human)

Functional Annotation PRO Centric View GO Centric View
PRO Term GO Annotation Evidence PR:000035412 hBUB1/Phos:7 Ser-593, MOD:00046|Thr-609, MOD:00047 acts_upstream_of_or_within GO:0034501 protein localization to kinetochore PMID:16760428 enables GO:0005515 protein binding increased relative to PR:000035414 Spom972h-BUB1/PhosRes- with PR:Q9NQS7 hINCENP PMID:16760428

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