back to PRO homepage
  Home |   Linked Open Data |   Browse |   Search |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Wiki
 PRO Consortium
 Publications
 Documentation

Protein Ontology Report - traf3:ticam1:ticam2:activated TLR4 complex (human)

PR:000036022 - http://purl.obolibrary.org/obo/PR_000036022
Ontology Information
PRO ID PR:000036022 Show OBO stanza / PAF
PRO name traf3:ticam1:ticam2:activated TLR4 complex (human)
Synonyms
EXACT: TRAF3:TRIF:TRAM:activated TLR4 (human)
Definition A traf3:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human. [PMID:16306936, PMID:16306937, Reactome:R-HSA-2201339]
Comment Requested by=TLR.
PRO Category organism-complex
Parent PR:000028681 traf3:ticam1:ticam2:activated TLR4 complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000036022 PR:Q13114 TNF receptor-associated factor 3 (human) hTRAF3 A TNF receptor-associated factor 3 that is encoded in the genome of human. [PRO:CNA] 2
PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM] 2
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] 2
PR:000040891 TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human) hTICAM2/iso:1/InitMet-/MyrPhos:1 A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at Gly-2 and phosphorylated at Ser-16 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068|Ser-16, MOD:00046. [PMID:16757566, PRO:DAN] 2
PR:000035702 CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human) hCD14/iso:1/Clv:2/anchored A CD14 molecule isoform 1 cleaved 2 GPI-anchored form in human. UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167. [Reactome:R-HSA-166033, Reactome:R-HSA-2201284] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2


Functional Annotation
PRO Term GO Annotation Evidence
PR:000036022
traf3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004842 ubiquitin-protein transferase activity Reactome:REACT_124037
located_in GO:0010008 endosome membrane Reactome:REACT_124037
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_124037
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037

top