Protein Ontology Report - DNMT1:PCNA:UHRF1 complex (human) PR:000037517 - http://purl.obolibrary.org/obo/PR_000037517

Ontology Information
PRO ID	PR:000037517 Show OBO stanza / PAF / GPI
PRO name	DNMT1:PCNA:UHRF1 complex (human)
Synonyms	Other: EXACT: DNMT1-PCNA-UHRF1 | DNMT1/PCNA/UHRF1
Definition	A methyltransferase complex that is composed of one subunit each of DNMT1, PCNA and UHRF1 in human. [PMID:20613874, PMID:21779454, PRO:KER]
Comment	Note: Promotes DNA methylation inheritance.
PRO Category	organism-complex
Parent	GO:0034708 methyltransferase complex
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-complex 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Complex Forms Display Category: All All organism-complex
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits

Complex PRO ID Name Short Label Definition Number in Complex PR:000037517 PR:P12004 proliferating cell nuclear antigen (human) hPCNA A proliferating cell nuclear antigen that is encoded in the genome of human. [PRO:DNx] 1 PR:Q96T88 E3 ubiquitin-protein ligase UHRF1 (human) hUHRF1 An E3 ubiquitin-protein ligase UHRF1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96T88] 1 PR:000037504 DNA (cytosine-5)-methyltransferase 1 unphosphorylated 1 (human) hDNMT1/UnPhos:1 A DNA (cytosine-5)-methyltransferase 1 (human) that lacks phosphorylated residues at positions equivalent to Ser-127 and Ser-143 of the amino acid sequence represented by UniProtKB:P26358-1. Example: UniProtKB:P26358-1, Ser-127/Ser-143, PR:000026291. [PMID:20613874, PRO:KER] 1

Functional Annotation PRO Centric View GO Centric View
PRO Term GO Annotation Evidence PR:000037517 DNMT1:PCNA:UHRF1 complex (human) associated_with_disease_suppression DOID:162 cancer PMID:20613874

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