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Protein Ontology Report - hSMAD2/iso:Long/UnPhos:1

PR:000045371 - http://purl.obolibrary.org/obo/PR_000045371
Ontology Information
PRO ID PR:000045371 Show OBO stanza / PAF
PRO name smad2 isoform Long unphosphorylated 1 (human)
Synonyms
PRO-short-label: hSMAD2/iso:Long/UnPhos:1
PRO-proteoform-std: UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291
Definition A mothers against decapentaplegic homolog 2 isoform Long (human) that lacks phosphorylation on the two last Ser of the C-terminal SSxS motif in human. UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291. [PRO:CNA]
PRO Category organism-modification
Parent PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human)
Taxon NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hSMAD2/iso:Long/UnPhos:1 forms found in complexes
hSMAD2/iso:Long/UnPhos:1 Component Complexes
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000045371
hSMAD2/iso:Long/UnPhos:1
Ser-465/Ser-467, PR:000026291
capable_of GO:0005515 protein binding PMID:8980228
located_in GO:0005737 cytoplasm PMID:15280432, PMID:17074053
located_in GO:0005769 early endosome PMID:12356868
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000045371 hSMAD2/iso:Long/UnPhos:1
Ser-465/Ser-467, PR:000026291
PMID:8752209
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005737 cytoplasm PR:000045371 hSMAD2/iso:Long/UnPhos:1
Ser-465/Ser-467, PR:000026291
PMID:15280432, PMID:17074053
GO:0005769 early endosome PR:000045371 hSMAD2/iso:Long/UnPhos:1
Ser-465/Ser-467, PR:000026291
PMID:12356868

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