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Protein Ontology Report - hTLR3

PR:O15455 - http://purl.obolibrary.org/obo/PR_O15455
This page represents a class of proteins encompassing all the protein products of the TLR3 gene in human .
Ontology Information
PRO ID PR:O15455 Show OBO stanza / PAF
PRO name Toll-like receptor 3 (human)
Synonyms
PRO-short-label: hTLR3
EXACT: CD283 (human)
Definition A Toll-like receptor 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O15455]
PRO Category organism-gene
Parent PR:000001154 Toll-like receptor 3
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 1
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTLR3 forms found in complexes
hTLR3 Component Complexes
PR:000001154 TLR3 PR:000037302 viral dsRNA:TLR3 complex
PR:000037305 hTLR3/SigPep- PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037344 traf6:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037332 rip3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037330 SARM:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037310 traf3:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037303 viral dsRNA:TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:000037305 hTLR3/SigPep- PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037366
fadd:rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037356
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037362
K63-pUb-rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037354
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037360
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037358
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037368
pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037322
p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037310
traf3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037338
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037303
viral dsRNA:TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037315
K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037307
ticam1:viral dsRNA:TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037330
SARM:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037344
traf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037332
rip3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037320
p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037334
rip1:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037340
pUbtraf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037336
rip1:rip3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037342
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000037303 viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037310 traf3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037332 rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway PR:000037330 SARM:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034138 toll-like receptor 3 signaling pathway PR:000037303 viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037310 traf3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037330 SARM:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037332 rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037303 viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037310 traf3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037330 SARM:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037332 rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037334 rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037344 traf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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