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Protein Ontology Report - hMAP3K7

PR:O43318 - http://purl.obolibrary.org/obo/PR_O43318
This page represents a class of proteins encompassing all the protein products of the MAP3K7 gene in human.
Ontology Information
PRO ID PR:O43318 Show OBO stanza / PAF
PRO name mitogen-activated protein kinase kinase kinase 7 (human)
Synonyms
PRO-short-label: hMAP3K7
EXACT: TGF-beta-activated kinase 1 (human); transforming growth factor-beta-activated kinase 1 (human)
Gene-based: MAP3K7; TAK1
Definition A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43318]
PRO Category organism-gene
Parent PR:000003158 mitogen-activated protein kinase kinase kinase 7
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 4
organism-modification 5
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hMAP3K7 forms found in complexes
hMAP3K7 Component Complexes
PR:000035736 hMAP3K7/Phos:1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035736 hMAP3K7/Phos:1 PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:000035736 hMAP3K7/Phos:1 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:O43318 hMAP3K7 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:O43318 hMAP3K7 PR:000035730 TAK1 kinase complex (human)
PR:O43318 hMAP3K7 PR:000028440 TAB2/TAK1 complex (human)
PR:O43318 hMAP3K7 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037338
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000035738
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26039
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035734
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036
located_in GO:0010008 endosome membrane Reactome:REACT_26036
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037342
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000035730
TAK1 kinase complex (human)
participates_in GO:0038095 Fc-epsilon receptor signaling pathway Reactome:REACT_163936
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000035740
free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
located_in GO:0005829 cytosol Reactome:REACT_23131
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_23131
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_23131
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0038095 Fc-epsilon receptor signaling pathway PR:000035730 TAK1 kinase complex (human)

Reactome:REACT_163936
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000035730 TAK1 kinase complex (human)

Reactome:REACT_6809
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Reactome:REACT_23131
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000035730 TAK1 kinase complex (human)

Reactome:REACT_25222
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Reactome:REACT_23131
GO:0034138 toll-like receptor 3 signaling pathway PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005829 cytosol PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Reactome:REACT_23131
GO:0010008 endosome membrane PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26036
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26039
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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