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Protein Ontology Report - hBUB1B

PR:O60566 - http://purl.obolibrary.org/obo/PR_O60566
This page represents a class of proteins encompassing all the protein products of the BUB1B gene in human .
Ontology Information
PRO ID PR:O60566 Show OBO stanza / PAF
PRO name mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)
Alternate ID PR:000026903
Synonyms
PRO-short-label: hBUB1B
EXACT: MAD3/BUB1-related protein kinase (human); hBUBR1; mitotic checkpoint kinase MAD3L (human); protein SSK1 (human)
RELATED: BUBR1; MAD3L; SSK1
Definition A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60566]
PRO Category organism-gene
Parent PR:000004855 mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 3
organism-modification 6
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hBUB1B forms found in complexes
hBUB1B Component Complexes
PR:000035373 hBUB1B/PhosRes- PR:000035579 BUB1:unphosphoBUB1B complex (human)
PR:000035428 hBUB1B/Phos:2 PR:000035577 BUB1:phosphoBUB1B complex (human)
PR:O60566 hBUB1B PR:000035563 BUB1B:BUB3 complex (human)
PR:O60566 hBUB1B PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human)
PR:O60566 hBUB1B PR:000035575 BUB1B:CDC20 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035362
hBUB1B/Phos:1
Thr-620, MOD:00047
capable_of GO:0005515 protein binding increased relative to PR:000035373 hBUB1B/PhosRes- with PR:P53350 hPLK1 PMID:17785528
PR:000035432
hBUB1B/Phos:3
Thr-608, MOD:00047
located_in GO:0000776 kinetochore PMID:22801780
participates_in GO:0001933 negative regulation of protein phosphorylation decreased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
participates_in GO:0034501 protein localization to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
participates_in GO:0031577 spindle checkpoint increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
participates_in GO:0034501 protein localization to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
participates_in GO:0007059 chromosome segregation increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
participates_in GO:0051310 metaphase plate congression increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
PR:000035435
hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
located_in GO:0000776 kinetochore PMID:19015317
participates_in GO:0008608 attachment of spindle microtubules to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:19015317, PMID:20016069
participates_in GO:0051310 metaphase plate congression increased relative to PR:000035373 hBUB1B/PhosRes- PMID:20016069
PR:000035373
hBUB1B/PhosRes-
capable_of GO:0005515 protein binding with PR:000035669 hPLK1/PhosRes- PMID:19503101
located_in GO:0000776 kinetochore PMID:22801780
located_in GO:0005813 centrosome PMID:19503101
participates_in GO:0033673 negative regulation of kinase activity PMID:19503101
participates_in GO:0010826 negative regulation of centrosome duplication PMID:19503101
participates_in GO:0001933 negative regulation of protein phosphorylation PMID:22801780
PR:O60566
hBUB1B
capable_of GO:0005515 protein binding with PR:Q02224 hCENPE PMID:17785528
capable_of GO:0005515 protein binding with PR:Q15013 hMAD2L1BP BioGRID:BG-719779
capable_of GO:0005515 protein binding with PR:O15350 hTP73 BioGRID:BG-717441
capable_of GO:0005515 protein binding with PR:O15379 hHDAC3 MINT:MINT-7302235
capable_of GO:0005515 protein binding with PR:Q92769 hHDAC2 MINT:MINT-7302197
capable_of GO:0005515 protein binding with PR:Q13042 hCDC16 PMID:11030144
capable_of GO:0005515 protein binding with PR:Q9UJX5 hANAPC4 BioGRID:BG-682429
capable_of GO:0005515 protein binding with PR:O76070 hSNCG BioGRID:BG-253351
capable_of GO:0005515 protein binding with PR:Q13547 hHDAC1 MINT:MINT-7302173
capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 PMID:11030144, PMID:20624902
capable_of GO:0005515 protein binding with PR:O43684 hBUB3 PMID:20016069
capable_of GO:0005515 protein binding with PR:Q9UJX3 hANAPC7 BioGRID:BG-316229
capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:11792804
capable_of GO:0005515 protein binding with PR:Q9H081 hMIS12 BioGRID:BG-715437
capable_of GO:0005515 protein binding with PR:Q96IF1 hAJUBA BioGRID:BG-717913
capable_of GO:0005515 protein binding with PR:P51587 hBRCA2 PMID:10749118
capable_of GO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:16760428, PMID:17785528
capable_of GO:0005515 protein binding with PR:000035449 hCDC27/Phos:1 PMID:11030144
capable_of GO:0005515 protein binding with PR:Q8NG31 hKNL1 BioGRID:BG-697203
capable_of GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302963
capable_of GO:0005515 protein binding with PR:P09874 hPARP1 BioGRID:BG-480411
capable_of GO:0005515 protein binding with PR:Q92831 hKAT2B MINT:MINT-7299740
capable_of GO:0005515 protein binding with PR:P04637-1 hTP53/iso:1 PMID:17671183
capable_of GO:0005515 protein binding with PR:P63010 hAP2B1 BioGRID:BG-283405
capable_of GO:0016301 kinase activity PMID:11030144
capable_of GO:0005515 protein binding with PR:P04049 hRAF1 PMID:20703093
capable_of GO:0005515 protein binding with PR:Q9H4B4 hPLK3 PMID:15190214
capable_of GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
capable_of GO:0005515 protein binding with PR:O95997 hPTTG1 BioGRID:BG-721860
capable_of GO:0005515 protein binding with PR:Q96GD4 hAURKB BioGRID:BG-717911
capable_of GO:0005515 protein binding with PR:000035450 hCDC27/PhosRes- PMID:11030144
capable_of GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512
capable_of GO:0005515 protein binding with PR:Q13257 hMAD2L1 PMID:20624902
located_in GO:0000939 condensed chromosome inner kinetochore PMID:11792804
located_in GO:0000922 spindle pole PMID:15190214
located_in GO:0000776 kinetochore PMID:12719470, PMID:16760428
located_in GO:0005737 cytoplasm PMID:10749118
located_in GO:0000940 condensed chromosome outer kinetochore PMID:11792804
participates_in GO:0031647 regulation of protein stability PMID:17671183
participates_in NOT GO:0034501 protein localization to kinetochore PMID:16760428
participates_in GO:0006469 negative regulation of protein kinase activity PMID:15592459
participates_in GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
participates_in GO:0031577 spindle checkpoint PMID:11030144
participates_in GO:0051310 metaphase plate congression PMID:12719470, PMID:15592459
participates_in GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512
participates_in GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PMID:15592459
PR:000035428
hBUB1B/Phos:2
capable_of GO:0004672 protein kinase activity increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779
capable_of GO:0005515 protein binding increased relative to PR:000035425 frog-BUB1B/PhosRes- with PR:Q15172 hPPP2R5A PMID:23079597
capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 PMID:11030144
capable_of GO:0005515 protein binding increased relative to PR:000035425 frog-BUB1B/PhosRes- with PR:O43683 hBUB1 PMID:11792804
located_in GO:0000776 kinetochore PMID:17785528
participates_in GO:0051310 metaphase plate congression increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779, PMID:17785528
participates_in GO:0008608 attachment of spindle microtubules to kinetochore increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528
participates_in GO:0006974 cellular response to DNA damage stimulus PMID:18440313
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0033673 negative regulation of kinase activity PR:000035373 hBUB1B/PhosRes-

PMID:19503101
GO:0008608 attachment of spindle microtubules to kinetochore PR:000035428 hBUB1B/Phos:2

increased relative to PR:000035425 frog-BUB1B/PhosRes-
PMID:17785528
PR:000035435 hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:19015317, PMID:20016069
GO:0006469 negative regulation of protein kinase activity PR:O60566 hBUB1B

PMID:15592459
GO:0001933 negative regulation of protein phosphorylation PR:000035373 hBUB1B/PhosRes-

PMID:22801780
PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
decreased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
NOT GO:0034501 protein localization to kinetochore PR:O60566 hBUB1B

PMID:16760428
GO:0031647 regulation of protein stability PR:O60566 hBUB1B

PMID:17671183
GO:0007059 chromosome segregation PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
GO:0006974 cellular response to DNA damage stimulus PR:000035428 hBUB1B/Phos:2

PMID:18440313
GO:0051444 negative regulation of ubiquitin-protein transferase activity PR:O60566 hBUB1B

PMID:15525512
PR:O60566 hBUB1B

PMID:15525512
GO:0034501 protein localization to kinetochore PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PR:O60566 hBUB1B

PMID:15592459
GO:0010826 negative regulation of centrosome duplication PR:000035373 hBUB1B/PhosRes-

PMID:19503101
GO:0031577 spindle checkpoint PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
PR:O60566 hBUB1B

PMID:11030144
GO:0051310 metaphase plate congression PR:000035428 hBUB1B/Phos:2

increased relative to PR:000035425 frog-BUB1B/PhosRes-
PMID:17376779, PMID:17785528
PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:22801780
PR:000035435 hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
increased relative to PR:000035373 hBUB1B/PhosRes-
PMID:20016069
PR:O60566 hBUB1B

PMID:12719470, PMID:15592459
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000940 condensed chromosome outer kinetochore PR:O60566 hBUB1B

PMID:11792804
GO:0005813 centrosome PR:000035373 hBUB1B/PhosRes-

PMID:19503101
GO:0005737 cytoplasm PR:O60566 hBUB1B

PMID:10749118
GO:0000939 condensed chromosome inner kinetochore PR:O60566 hBUB1B

PMID:11792804
GO:0000776 kinetochore PR:000035373 hBUB1B/PhosRes-

PMID:22801780
PR:000035428 hBUB1B/Phos:2

PMID:17785528
PR:000035432 hBUB1B/Phos:3
Thr-608, MOD:00047
PMID:22801780
PR:000035435 hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
PMID:19015317
PR:O60566 hBUB1B

PMID:12719470, PMID:16760428
GO:0000922 spindle pole PR:O60566 hBUB1B

PMID:15190214

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