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Protein Ontology Report - hPML

PR:P29590 - http://purl.obolibrary.org/obo/PR_P29590
This page represents a class of proteins encompassing all the protein products of the PML gene in human .
Ontology Information
PRO ID PR:P29590 Show OBO stanza / PAF
PRO name protein PML (human)
Synonyms
PRO-short-label: hPML
EXACT: RING finger protein 71 (human); promyelocytic leukemia protein (human); tripartite motif-containing protein 19 (human)
RELATED: MYL; PP8675; RNF71; TRIM19
Definition A transcription factor PML that is encoded in the genome of human. [PRO:CNA, UniProtKB:P29590]
PRO Category organism-gene
Parent PR:000026474 transcription factor PML
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 12
organism-modification 1
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P29590-3
hPML/iso:3
capable_of GO:0005515 protein binding with PR:P06400 hRB1 PMID:9448006
capable_of GO:0005515 protein binding with PR:P45481 mCREBBP PMID:10610177
capable_of GO:0046982 protein heterodimerization activity PMID:7935403
capable_of GO:0005515 protein binding with PR:Q64127 mTRIM24 PMID:10610177
capable_of GO:0005515 protein binding with PR:P04489 E4orf3 (ADE05) PMID:16501113
located_in GO:0031965 nuclear membrane PMID:16778193
located_in GO:0005634 nucleus PMID:9294197
located_in GO:0005737 cytoplasm PMID:16778193
participates_in GO:0030578 PML body organization PMID:10779416
participates_in GO:0006915 apoptotic process PMID:9583681
participates_in GO:0007050 cell cycle arrest PMID:9583681
participates_in GO:0030308 negative regulation of cell growth PMID:9395203
participates_in GO:0045930 negative regulation of mitotic cell cycle PMID:9395203
participates_in GO:0030308 negative regulation of cell growth PMID:9583681
participates_in GO:0030308 negative regulation of cell growth PMID:7935403
PR:P29590-2
hPML/iso:2
located_in GO:0005737 cytoplasm PMID:16778193
located_in GO:0005634 nucleus PMID:16778193
participates_in GO:0002230 positive regulation of defense response to virus by host PMID:16873256
PR:P29590-1
hPML/iso:1
capable_of GO:0005515 protein binding with PR:Q13164 hMAPK7 PMID:20832753
located_in GO:0005737 cytoplasm PMID:9885291
located_in GO:0005737 cytoplasm PMID:16778193
located_in GO:0005634 nucleus PMID:16778193
PR:P29590-5
hPML/iso:5
capable_of GO:0005515 protein binding with PR:Q00987 hMDM2 PMID:12915590
capable_of GO:0005515 protein binding with PR:O15379 hHDAC3 PMID:11259576
capable_of GO:0005515 protein binding with PR:Q92547 hTOPBP1 PMID:12773567
capable_of GO:0005515 protein binding with PR:Q13547 hHDAC1 PMID:11259576
capable_of GO:0005515 protein binding with PR:Q05516 hZBTB16 PMID:9294197
capable_of GO:0005515 protein binding with PR:O96017 hCHEK2 PMID:12402044
capable_of GO:0005515 protein binding with PR:Q00987 hMDM2 PMID:12915590
capable_of GO:0005515 protein binding with PR:P62913 hRPL11 PMID:15195100
capable_of GO:0005515 protein binding with PR:P06400 hRB1 PMID:9448006
capable_of GO:0005515 protein binding with PR:Q92769 hHDAC2 PMID:11259576
capable_of GO:0005515 protein binding with PR:Q05516 hZBTB16 PMID:9294197
capable_of GO:0005515 protein binding with PR:P04637 hTP53 PMID:11080164
capable_of GO:0003713 transcription coactivator activity PMID:15626733
capable_of GO:0003713 transcription coactivator activity PMID:11080164
located_in GO:0005737 cytoplasm PMID:16778193
located_in GO:0016605 PML body PMID:9448006
located_in GO:0016363 nuclear matrix PMID:11080164
located_in GO:0005730 nucleolus PMID:16778193
participates_in GO:0006915 apoptotic process PMID:11080164
participates_in GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage PMID:12402044
participates_in GO:0006605 protein targeting PMID:11080164
participates_in GO:0050821 protein stabilization PMID:12773567
participates_in GO:0031065 positive regulation of histone deacetylation PMID:11259576
participates_in GO:0007050 cell cycle arrest PMID:12773567
participates_in GO:0030308 negative regulation of cell growth PMID:9448006
participates_in GO:0032938 negative regulation of translation in response to oxidative stress PMID:16915281
participates_in GO:0045892 negative regulation of transcription, DNA-templated PMID:9448006
participates_in GO:0006605 protein targeting PMID:15195100
PR:P29590-4
hPML/iso:4
capable_of GO:0005515 protein binding with PR:P63279 hUBE2I PMID:9885291
capable_of GO:0005515 protein binding with PR:P23769 hGATA2 PMID:10938104
capable_of GO:0005515 protein binding with PR:P14373 hTRIM27 PMID:9570750
capable_of GO:0005515 protein binding with PR:Q9UER7-1 hDAXX/iso:1 PMID:10669754
capable_of GO:0005515 protein binding with PR:P63073 mEIF4E PMID:11500381
capable_of GO:0008270 zinc ion binding PMID:7729428
capable_of GO:0050897 cobalt ion binding PMID:7729428
capable_of GO:0005515 protein binding with PR:Q03014 hHHEX PMID:10597310
capable_of GO:0005515 protein binding with PR:P63165 hSUMO1 PMID:9885291
located_in GO:0016605 PML body PMID:9885291
participates_in GO:0030578 PML body organization PMID:8643677
participates_in GO:0002230 positive regulation of defense response to virus by host PMID:16873257
PR:000026480
hPML/iso:1/Phos:1
Ser-403, MOD:00046|Thr-409, MOD:00047
located_in GO:0005634 nucleus PMID:20832753
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007050 cell cycle arrest PR:P29590-3 hPML/iso:3

PMID:9583681
PR:P29590-5 hPML/iso:5

PMID:12773567
GO:0006605 protein targeting PR:P29590-5 hPML/iso:5

PMID:11080164
PR:P29590-5 hPML/iso:5

PMID:15195100
GO:0031065 positive regulation of histone deacetylation PR:P29590-5 hPML/iso:5

PMID:11259576
GO:0032938 negative regulation of translation in response to oxidative stress PR:P29590-5 hPML/iso:5

PMID:16915281
GO:0030308 negative regulation of cell growth PR:P29590-3 hPML/iso:3

PMID:9395203
PR:P29590-3 hPML/iso:3

PMID:9583681
PR:P29590-3 hPML/iso:3

PMID:7935403
PR:P29590-5 hPML/iso:5

PMID:9448006
GO:0045892 negative regulation of transcription, DNA-templated PR:P29590-5 hPML/iso:5

PMID:9448006
GO:0006915 apoptotic process PR:P29590-3 hPML/iso:3

PMID:9583681
PR:P29590-5 hPML/iso:5

PMID:11080164
GO:0050821 protein stabilization PR:P29590-5 hPML/iso:5

PMID:12773567
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage PR:P29590-5 hPML/iso:5

PMID:12402044
GO:0002230 positive regulation of defense response to virus by host PR:P29590-2 hPML/iso:2

PMID:16873256
PR:P29590-4 hPML/iso:4

PMID:16873257
GO:0030578 PML body organization PR:P29590-3 hPML/iso:3

PMID:10779416
PR:P29590-4 hPML/iso:4

PMID:8643677
GO:0045930 negative regulation of mitotic cell cycle PR:P29590-3 hPML/iso:3

PMID:9395203
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0016363 nuclear matrix PR:P29590-5 hPML/iso:5

PMID:11080164
GO:0016605 PML body PR:P29590-4 hPML/iso:4

PMID:9885291
PR:P29590-5 hPML/iso:5

PMID:9448006
GO:0005737 cytoplasm PR:P29590-1 hPML/iso:1

PMID:9885291
PR:P29590-1 hPML/iso:1

PMID:16778193
PR:P29590-2 hPML/iso:2

PMID:16778193
PR:P29590-3 hPML/iso:3

PMID:16778193
PR:P29590-5 hPML/iso:5

PMID:16778193
GO:0005730 nucleolus PR:P29590-5 hPML/iso:5

PMID:16778193
GO:0031965 nuclear membrane PR:P29590-3 hPML/iso:3

PMID:16778193
GO:0005634 nucleus PR:000026480 hPML/iso:1/Phos:1
Ser-403, MOD:00046|Thr-409, MOD:00047
PMID:20832753
PR:P29590-1 hPML/iso:1

PMID:16778193
PR:P29590-2 hPML/iso:2

PMID:16778193
PR:P29590-3 hPML/iso:3

PMID:9294197

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